The influence of type 1 diabetes on pancreatic weight

Martha L. Campbell-Thompson, John S. Kaddis, Clive Wasserfall, Michael J. Haller, Alberto Pugliese, Desmond A. Schatz, Jonathan J. Shuster, Mark A. Atkinson

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Aims/hypothesis: Previous studies of pancreases obtained at autopsy or by radiography note reduced pancreas weight (PW) and size, respectively, in type 1 diabetes; this finding is widely considered to be the result of chronic insulinopenia. This literature is, however, limited with respect to the influence of age, sex, anthropometric factors and disease duration on these observations. Moreover, data are sparse for young children, a group of particular interest for type 1 diabetes. We hypothesised that the pancreas-to-body weight ratio would normalise confounding inter-subject factors, thereby permitting better characterisation of PW in type 1 diabetes. Methods: Transplant-grade pancreases were recovered from 216 organ donors with type 1 diabetes (n = 90), type 2 diabetes (n = 40) and no diabetes (n = 86). Whole-organ and head, body and tail weights were determined. The relative PW (RPW; PW [g] / body weight [kg]) was calculated and tested for normalisation of potential differences due to age, sex and BMI. Results: PW significantly correlated with body weight in control donors (R2 = 0.76, p <0.001) while RPW (1.03 ± 0.36, mean ± SD) did not significantly differ across ages (0–58 years). Donors with type 1 diabetes (0.57 ± 0.18, p <0.001), but not those with type 2 diabetes (0.93 ± 0.30), had significantly lower RPW. The relative weights of each pancreatic region from donors with type 1 diabetes were significantly smaller than those of regions from control donors and donors with type 2 diabetes (p <0.001). Perhaps most interestingly, the RPW was not significantly associated with duration of type 1 diabetes or type 2 diabetes. Conclusions/interpretation: RPW allows for comparisons across a wide range of donor ages by eliminating confounding variables. These data validate an interesting feature of the type 1 diabetes pancreas and underscore the need for additional studies to identify the mechanistic basis for this finding, including those beyond the chronic loss of endogenous insulin secretion.

Original languageEnglish (US)
Pages (from-to)217-221
Number of pages5
JournalDiabetologia
Volume59
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Type 1 Diabetes Mellitus
Pancreas
Weights and Measures
Tissue Donors
Type 2 Diabetes Mellitus
Body Weight
Sex Factors
Public Opinion
Confounding Factors (Epidemiology)
Radiography
Autopsy
Head
Insulin
Transplants

Keywords

  • Children
  • Organ donor
  • Pancreas
  • Pancreas weight
  • Type 1 diabetes
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Campbell-Thompson, M. L., Kaddis, J. S., Wasserfall, C., Haller, M. J., Pugliese, A., Schatz, D. A., ... Atkinson, M. A. (2016). The influence of type 1 diabetes on pancreatic weight. Diabetologia, 59(1), 217-221. https://doi.org/10.1007/s00125-015-3752-z

The influence of type 1 diabetes on pancreatic weight. / Campbell-Thompson, Martha L.; Kaddis, John S.; Wasserfall, Clive; Haller, Michael J.; Pugliese, Alberto; Schatz, Desmond A.; Shuster, Jonathan J.; Atkinson, Mark A.

In: Diabetologia, Vol. 59, No. 1, 01.01.2016, p. 217-221.

Research output: Contribution to journalArticle

Campbell-Thompson, ML, Kaddis, JS, Wasserfall, C, Haller, MJ, Pugliese, A, Schatz, DA, Shuster, JJ & Atkinson, MA 2016, 'The influence of type 1 diabetes on pancreatic weight', Diabetologia, vol. 59, no. 1, pp. 217-221. https://doi.org/10.1007/s00125-015-3752-z
Campbell-Thompson ML, Kaddis JS, Wasserfall C, Haller MJ, Pugliese A, Schatz DA et al. The influence of type 1 diabetes on pancreatic weight. Diabetologia. 2016 Jan 1;59(1):217-221. https://doi.org/10.1007/s00125-015-3752-z
Campbell-Thompson, Martha L. ; Kaddis, John S. ; Wasserfall, Clive ; Haller, Michael J. ; Pugliese, Alberto ; Schatz, Desmond A. ; Shuster, Jonathan J. ; Atkinson, Mark A. / The influence of type 1 diabetes on pancreatic weight. In: Diabetologia. 2016 ; Vol. 59, No. 1. pp. 217-221.
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