The influence of DL-methionine on the metabolism of S-adenosylethionine in rats chronically treated with DL-ethionine

Z. Brada, S. Bulba, N. H. Altman

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The concentration of S adenosylethionine in the liver of ethionine fed rats was increased gradually during the process of carcinogenesis. This increase may have been due to the decreased capacity of the treated rats to acetylate ethionine sulfoxide. Ethionine sulfoxide is considered as the main reserve pool of ethionine for the synthesis of S adenosylethionine. When the ethionine diet was supplemented by D methionine (0.3 to 0.9%), the increase in the concentration of S adenosylethionine during the period of observation (28 to 150 days) was lower and the acetylation of ethionine sulfoxide was significantly higher. The concentration of the total S adenosyl compounds in the liver of rats on a diet supplemented with DL methionine was increased over the concentration of S adenosylethionine in rats fed ethionine alone, and the S adenosylethionine portion of this fraction was only about 30% lower. The supplementation of the diet with methionine restored the diurnal oscillation of adenosine 5' triphosphate in the liver, which had been absent in rats ingesting only ethionine.

Original languageEnglish
Pages (from-to)1573-1579
Number of pages7
JournalCancer Research
Volume36
Issue number5
StatePublished - Dec 1 1976
Externally publishedYes

Fingerprint

Ethionine
Methionine
sulfoxide
Diet
Liver
S-adenosylethionine
Acetylation
Carcinogenesis
Adenosine Triphosphate
Observation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The influence of DL-methionine on the metabolism of S-adenosylethionine in rats chronically treated with DL-ethionine. / Brada, Z.; Bulba, S.; Altman, N. H.

In: Cancer Research, Vol. 36, No. 5, 01.12.1976, p. 1573-1579.

Research output: Contribution to journalArticle

@article{ea8df1062d9d4043a2b22dc5dc2d1a68,
title = "The influence of DL-methionine on the metabolism of S-adenosylethionine in rats chronically treated with DL-ethionine",
abstract = "The concentration of S adenosylethionine in the liver of ethionine fed rats was increased gradually during the process of carcinogenesis. This increase may have been due to the decreased capacity of the treated rats to acetylate ethionine sulfoxide. Ethionine sulfoxide is considered as the main reserve pool of ethionine for the synthesis of S adenosylethionine. When the ethionine diet was supplemented by D methionine (0.3 to 0.9{\%}), the increase in the concentration of S adenosylethionine during the period of observation (28 to 150 days) was lower and the acetylation of ethionine sulfoxide was significantly higher. The concentration of the total S adenosyl compounds in the liver of rats on a diet supplemented with DL methionine was increased over the concentration of S adenosylethionine in rats fed ethionine alone, and the S adenosylethionine portion of this fraction was only about 30{\%} lower. The supplementation of the diet with methionine restored the diurnal oscillation of adenosine 5' triphosphate in the liver, which had been absent in rats ingesting only ethionine.",
author = "Z. Brada and S. Bulba and Altman, {N. H.}",
year = "1976",
month = "12",
day = "1",
language = "English",
volume = "36",
pages = "1573--1579",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "5",

}

TY - JOUR

T1 - The influence of DL-methionine on the metabolism of S-adenosylethionine in rats chronically treated with DL-ethionine

AU - Brada, Z.

AU - Bulba, S.

AU - Altman, N. H.

PY - 1976/12/1

Y1 - 1976/12/1

N2 - The concentration of S adenosylethionine in the liver of ethionine fed rats was increased gradually during the process of carcinogenesis. This increase may have been due to the decreased capacity of the treated rats to acetylate ethionine sulfoxide. Ethionine sulfoxide is considered as the main reserve pool of ethionine for the synthesis of S adenosylethionine. When the ethionine diet was supplemented by D methionine (0.3 to 0.9%), the increase in the concentration of S adenosylethionine during the period of observation (28 to 150 days) was lower and the acetylation of ethionine sulfoxide was significantly higher. The concentration of the total S adenosyl compounds in the liver of rats on a diet supplemented with DL methionine was increased over the concentration of S adenosylethionine in rats fed ethionine alone, and the S adenosylethionine portion of this fraction was only about 30% lower. The supplementation of the diet with methionine restored the diurnal oscillation of adenosine 5' triphosphate in the liver, which had been absent in rats ingesting only ethionine.

AB - The concentration of S adenosylethionine in the liver of ethionine fed rats was increased gradually during the process of carcinogenesis. This increase may have been due to the decreased capacity of the treated rats to acetylate ethionine sulfoxide. Ethionine sulfoxide is considered as the main reserve pool of ethionine for the synthesis of S adenosylethionine. When the ethionine diet was supplemented by D methionine (0.3 to 0.9%), the increase in the concentration of S adenosylethionine during the period of observation (28 to 150 days) was lower and the acetylation of ethionine sulfoxide was significantly higher. The concentration of the total S adenosyl compounds in the liver of rats on a diet supplemented with DL methionine was increased over the concentration of S adenosylethionine in rats fed ethionine alone, and the S adenosylethionine portion of this fraction was only about 30% lower. The supplementation of the diet with methionine restored the diurnal oscillation of adenosine 5' triphosphate in the liver, which had been absent in rats ingesting only ethionine.

UR - http://www.scopus.com/inward/record.url?scp=0017140213&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017140213&partnerID=8YFLogxK

M3 - Article

VL - 36

SP - 1573

EP - 1579

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 5

ER -