The influence of different types of alcoholic beverages on disrupting highly active antiretroviral treatment (HAART) outcome

María José Míguez-Burbano, John E Lewis, Joel Fishman, Deshratn Asthana, Robert M. Malow

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Aims: Studies have yielded conflicting results regarding alcohol's influence on HIV outcomes, particularly after highly active antiretroviral treatment (HAART). Discrepant findings may be related to confounding variables, including gender, patterns of alcohol abuse and type of alcohol beverage beyond the amount consumed. Methods: Using a cohort study, differences in HAART effectiveness after 24 weeks of therapy were compared as a function of amount and preference for alcohol, drinking only liquor (LI, n = 55) or only wine or beer (BW, n = 110). Given the critical role of thymus on HAART response, changes in thymus size, CD4s, naïve lymphocytes and viral loads were assessed. Results: After HAART, positive increases in both CD4s (+12 cell counts/mm3) and thymus size (+0.7 mm3) were evident in the BW group. In contrast, the LI subgroup exhibited a decline in both parameters (-4 CD4 cells/mm3 and -0.6 mm3 in thymus size). Women in the LI group exhibited significantly lower CD4 (163.4 ± 46.2) and naïve counts (178 ± 69.5) than LI men (CD4: 281.6 ± 203, P = 0.05; lymphocytes: 301.4 ± 198, P = 0.04). In adjusted regression models, the LI compared to the BW subgroup had greater odds of maintaining detectable viral loads (RR = 1.35, 95% CI 1.04-1.75; P = 0.03), increased thymus volumes (RR = 3.8, P = 0.04) and replenished naïve cells (RR = 13, P = 0.02). Conclusions: Liquor was associated with thymus deterioration and thus with poorer viro-immune outcomes after HAART. Subtyping participants by alcohol consumption patterns seems to be clinically relevant and needs to be accounted for in future studies.

Original languageEnglish
Pages (from-to)366-371
Number of pages6
JournalAlcohol and Alcoholism
Volume44
Issue number4
DOIs
StatePublished - Jul 16 2009

Fingerprint

Thymus
Alcoholic Beverages
Thymus Gland
Alcohols
Lymphocytes
Viral Load
Alcohol Drinking
Therapeutics
Beer
Confounding Factors (Epidemiology)
Beverages
Wine
Alcoholism
Deterioration
Alcoholic beverages
Cohort Studies
Cell Count
HIV

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Cite this

The influence of different types of alcoholic beverages on disrupting highly active antiretroviral treatment (HAART) outcome. / Míguez-Burbano, María José; Lewis, John E; Fishman, Joel; Asthana, Deshratn; Malow, Robert M.

In: Alcohol and Alcoholism, Vol. 44, No. 4, 16.07.2009, p. 366-371.

Research output: Contribution to journalArticle

Míguez-Burbano, María José ; Lewis, John E ; Fishman, Joel ; Asthana, Deshratn ; Malow, Robert M. / The influence of different types of alcoholic beverages on disrupting highly active antiretroviral treatment (HAART) outcome. In: Alcohol and Alcoholism. 2009 ; Vol. 44, No. 4. pp. 366-371.
@article{37f801e118434b7e8de2cfa9c0c3a23c,
title = "The influence of different types of alcoholic beverages on disrupting highly active antiretroviral treatment (HAART) outcome",
abstract = "Aims: Studies have yielded conflicting results regarding alcohol's influence on HIV outcomes, particularly after highly active antiretroviral treatment (HAART). Discrepant findings may be related to confounding variables, including gender, patterns of alcohol abuse and type of alcohol beverage beyond the amount consumed. Methods: Using a cohort study, differences in HAART effectiveness after 24 weeks of therapy were compared as a function of amount and preference for alcohol, drinking only liquor (LI, n = 55) or only wine or beer (BW, n = 110). Given the critical role of thymus on HAART response, changes in thymus size, CD4s, na{\"i}ve lymphocytes and viral loads were assessed. Results: After HAART, positive increases in both CD4s (+12 cell counts/mm3) and thymus size (+0.7 mm3) were evident in the BW group. In contrast, the LI subgroup exhibited a decline in both parameters (-4 CD4 cells/mm3 and -0.6 mm3 in thymus size). Women in the LI group exhibited significantly lower CD4 (163.4 ± 46.2) and na{\"i}ve counts (178 ± 69.5) than LI men (CD4: 281.6 ± 203, P = 0.05; lymphocytes: 301.4 ± 198, P = 0.04). In adjusted regression models, the LI compared to the BW subgroup had greater odds of maintaining detectable viral loads (RR = 1.35, 95{\%} CI 1.04-1.75; P = 0.03), increased thymus volumes (RR = 3.8, P = 0.04) and replenished na{\"i}ve cells (RR = 13, P = 0.02). Conclusions: Liquor was associated with thymus deterioration and thus with poorer viro-immune outcomes after HAART. Subtyping participants by alcohol consumption patterns seems to be clinically relevant and needs to be accounted for in future studies.",
author = "M{\'i}guez-Burbano, {Mar{\'i}a Jos{\'e}} and Lewis, {John E} and Joel Fishman and Deshratn Asthana and Malow, {Robert M.}",
year = "2009",
month = "7",
day = "16",
doi = "10.1093/alcalc/agp024",
language = "English",
volume = "44",
pages = "366--371",
journal = "Alcohol and Alcoholism",
issn = "0735-0414",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - The influence of different types of alcoholic beverages on disrupting highly active antiretroviral treatment (HAART) outcome

AU - Míguez-Burbano, María José

AU - Lewis, John E

AU - Fishman, Joel

AU - Asthana, Deshratn

AU - Malow, Robert M.

PY - 2009/7/16

Y1 - 2009/7/16

N2 - Aims: Studies have yielded conflicting results regarding alcohol's influence on HIV outcomes, particularly after highly active antiretroviral treatment (HAART). Discrepant findings may be related to confounding variables, including gender, patterns of alcohol abuse and type of alcohol beverage beyond the amount consumed. Methods: Using a cohort study, differences in HAART effectiveness after 24 weeks of therapy were compared as a function of amount and preference for alcohol, drinking only liquor (LI, n = 55) or only wine or beer (BW, n = 110). Given the critical role of thymus on HAART response, changes in thymus size, CD4s, naïve lymphocytes and viral loads were assessed. Results: After HAART, positive increases in both CD4s (+12 cell counts/mm3) and thymus size (+0.7 mm3) were evident in the BW group. In contrast, the LI subgroup exhibited a decline in both parameters (-4 CD4 cells/mm3 and -0.6 mm3 in thymus size). Women in the LI group exhibited significantly lower CD4 (163.4 ± 46.2) and naïve counts (178 ± 69.5) than LI men (CD4: 281.6 ± 203, P = 0.05; lymphocytes: 301.4 ± 198, P = 0.04). In adjusted regression models, the LI compared to the BW subgroup had greater odds of maintaining detectable viral loads (RR = 1.35, 95% CI 1.04-1.75; P = 0.03), increased thymus volumes (RR = 3.8, P = 0.04) and replenished naïve cells (RR = 13, P = 0.02). Conclusions: Liquor was associated with thymus deterioration and thus with poorer viro-immune outcomes after HAART. Subtyping participants by alcohol consumption patterns seems to be clinically relevant and needs to be accounted for in future studies.

AB - Aims: Studies have yielded conflicting results regarding alcohol's influence on HIV outcomes, particularly after highly active antiretroviral treatment (HAART). Discrepant findings may be related to confounding variables, including gender, patterns of alcohol abuse and type of alcohol beverage beyond the amount consumed. Methods: Using a cohort study, differences in HAART effectiveness after 24 weeks of therapy were compared as a function of amount and preference for alcohol, drinking only liquor (LI, n = 55) or only wine or beer (BW, n = 110). Given the critical role of thymus on HAART response, changes in thymus size, CD4s, naïve lymphocytes and viral loads were assessed. Results: After HAART, positive increases in both CD4s (+12 cell counts/mm3) and thymus size (+0.7 mm3) were evident in the BW group. In contrast, the LI subgroup exhibited a decline in both parameters (-4 CD4 cells/mm3 and -0.6 mm3 in thymus size). Women in the LI group exhibited significantly lower CD4 (163.4 ± 46.2) and naïve counts (178 ± 69.5) than LI men (CD4: 281.6 ± 203, P = 0.05; lymphocytes: 301.4 ± 198, P = 0.04). In adjusted regression models, the LI compared to the BW subgroup had greater odds of maintaining detectable viral loads (RR = 1.35, 95% CI 1.04-1.75; P = 0.03), increased thymus volumes (RR = 3.8, P = 0.04) and replenished naïve cells (RR = 13, P = 0.02). Conclusions: Liquor was associated with thymus deterioration and thus with poorer viro-immune outcomes after HAART. Subtyping participants by alcohol consumption patterns seems to be clinically relevant and needs to be accounted for in future studies.

UR - http://www.scopus.com/inward/record.url?scp=67650233331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650233331&partnerID=8YFLogxK

U2 - 10.1093/alcalc/agp024

DO - 10.1093/alcalc/agp024

M3 - Article

C2 - 19454401

AN - SCOPUS:67650233331

VL - 44

SP - 366

EP - 371

JO - Alcohol and Alcoholism

JF - Alcohol and Alcoholism

SN - 0735-0414

IS - 4

ER -