TY - JOUR
T1 - The influence of demographic factors on functional capacity and everyday functional outcomes in schizophrenia
AU - Gould, Felicia
AU - Bowie, Christopher R.
AU - Harvey, Philip D.
N1 - Funding Information:
Disclosure Statement: F. Gould receives salary support from a clinical trial funded by Sunovion. C. R. Bowie has served as a consultant to Abbott Laboratories and has received a grant from Johnson and Johnson. P. D. Harvey has received consulting fees from Abbott Labs, Boehringer-Ingleheim, Bristol Myers Squibb, En Vivo, Genentech, Johnson and Johnson, Pharma Neuro Boost, Sunovion Pharma, and Takeda Pharma, during the past year. This study was funded by the National Institute of Mental Health (NIMH; Grants MH 63116 and 78775 to P. D. Harvey) and is unrelated to any outside activities.
PY - 2012/6/1
Y1 - 2012/6/1
N2 - Patients with schizophrenia have impaired everyday living and social outcomes. Performance-based measures, including neuropsychological (NP) performance and functional capacity (FC) measures have demonstrated usefulness in predicting these outcomes. We examined the correlation of demographic factors (race, age, and education) and FC measures, and the relative ability of NP performance, FC, and demographic factors to predict real-world outcomes in social, vocational, and residential domains in 194 outpatients with schizophrenia. Age, education, sex, and racial status were significantly, but modestly, associated with performance-based measures of everyday functioning, while, in addition, age and education had a similar modest relationship with social competence. Age, but none of the other demographic variables, contributed to the prediction of all three domains of everyday functioning. Functional capacity variables predicted everyday outcomes even when demographic variables were entered into a predictive equation first. These data suggest a similar and modest but detectable effect of demographic factors on performance-based measures of functional capacity as seen with NP performance in schizophrenia populations. Older age contributed to poorer everyday functioning even after consideration of functional capacity, which seems similar to findings in healthy populations without clinically notable cognitive decline.
AB - Patients with schizophrenia have impaired everyday living and social outcomes. Performance-based measures, including neuropsychological (NP) performance and functional capacity (FC) measures have demonstrated usefulness in predicting these outcomes. We examined the correlation of demographic factors (race, age, and education) and FC measures, and the relative ability of NP performance, FC, and demographic factors to predict real-world outcomes in social, vocational, and residential domains in 194 outpatients with schizophrenia. Age, education, sex, and racial status were significantly, but modestly, associated with performance-based measures of everyday functioning, while, in addition, age and education had a similar modest relationship with social competence. Age, but none of the other demographic variables, contributed to the prediction of all three domains of everyday functioning. Functional capacity variables predicted everyday outcomes even when demographic variables were entered into a predictive equation first. These data suggest a similar and modest but detectable effect of demographic factors on performance-based measures of functional capacity as seen with NP performance in schizophrenia populations. Older age contributed to poorer everyday functioning even after consideration of functional capacity, which seems similar to findings in healthy populations without clinically notable cognitive decline.
KW - Cognition
KW - Demographic factors
KW - Disability
KW - Functional capacity
KW - Schizophrenia
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U2 - 10.1080/13803395.2011.651102
DO - 10.1080/13803395.2011.651102
M3 - Article
C2 - 22272559
AN - SCOPUS:84860486042
VL - 34
SP - 467
EP - 475
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
SN - 1380-3395
IS - 5
ER -