The influence of comorbid depression on quality of life for people with epilepsy

Joyce A. Cramer, David Blum, Michael Reed, Kristina Fanning, Patricia Dean, Alan Ettinger, Patricia Gibson, Frank Gilliam, Cynthia Harden, Andrew Kanner, Patricia Shafer

Research output: Contribution to journalArticlepeer-review

168 Scopus citations


The impact of depression on health-related quality of life (HRQOL) for people with epilepsy was evaluated using a postal survey that assessed HRQOL, depression, and seizure severity (N = 501). QOLIE-89 scores were significantly reduced by comorbid depression (all P < 0.0001) for all types of seizures. People with predominantly major, partial, and minor seizures had significantly poorer HRQOL if they had mild-moderate or major depression (all P < 0.0001). People with any type of recent seizure had significantly poorer HRQOL in all domains than people who were seizure-free for 3 months. Differences between groups by depression category were clinically significant (> 12 points). Depression (r = -0.72), seizure bothersomeness (r = -0.54), seizure severity (r = -0.37), and days disabled with seizures (r = -0.65 were significantly correlated with poorer HRQOL in all domains than found for nondepressed patients (all subscales P < 0.0001). Clinical depression is significantly associated with poorer HRQOL among people with all types of seizures.

Original languageEnglish (US)
Pages (from-to)515-521
Number of pages7
JournalEpilepsy and Behavior
Issue number5
StatePublished - Oct 2003
Externally publishedYes


  • Depression
  • Epilepsy
  • Quality of life
  • Seizures

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience


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