The influence of age on the onset of anaesthesia with midazolam

J. W. Dundee, N. J. Halliday, P. G. Loughran, K. W. Harper

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

There was a considerable individual variation in response to a standard induction dose of 0.3 mg/kg midazolam in unpremedicated patients. This is shown by variations in time to onset of sleep and the fact that about one quarter of subjects did not lose consciousness in 3 minutes. In 166 fit patients a good negative correlation was demonstrated between the age of the patients and time to loss of consciousness. Patients over 50 years differed from younger patients in a greater reliability of effect and significantly shorter induction time. In elderly patients midazolam is a more reliable induction agent than in the young.

Original languageEnglish
Pages (from-to)441-443
Number of pages3
JournalAnaesthesia
Volume40
Issue number5
StatePublished - Jan 1 1985
Externally publishedYes

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Midazolam
Age of Onset
Anesthesia
Unconsciousness
Consciousness
Sleep

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Dundee, J. W., Halliday, N. J., Loughran, P. G., & Harper, K. W. (1985). The influence of age on the onset of anaesthesia with midazolam. Anaesthesia, 40(5), 441-443.

The influence of age on the onset of anaesthesia with midazolam. / Dundee, J. W.; Halliday, N. J.; Loughran, P. G.; Harper, K. W.

In: Anaesthesia, Vol. 40, No. 5, 01.01.1985, p. 441-443.

Research output: Contribution to journalArticle

Dundee, JW, Halliday, NJ, Loughran, PG & Harper, KW 1985, 'The influence of age on the onset of anaesthesia with midazolam', Anaesthesia, vol. 40, no. 5, pp. 441-443.
Dundee JW, Halliday NJ, Loughran PG, Harper KW. The influence of age on the onset of anaesthesia with midazolam. Anaesthesia. 1985 Jan 1;40(5):441-443.
Dundee, J. W. ; Halliday, N. J. ; Loughran, P. G. ; Harper, K. W. / The influence of age on the onset of anaesthesia with midazolam. In: Anaesthesia. 1985 ; Vol. 40, No. 5. pp. 441-443.
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