The influence of age on the onset of anaesthesia with midazolam

J. W. DUNDEE, N. J. HALLIDAY, P. G. LOUGHRAN, K. W. HARPER

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Abstract

There was a considerable individual variation in response to a standard induction dose of 0.3 mg/kg midazolam in unpremedicated patients. This is shown by variations in time to onset of sleep and the fact that about one quarter of subjects did not lose consciousness in 3 minutes. In 166 fit patients a good negative correlation was demonstrated between the age of the patients and time to loss of consciousness. Patients over 50 years differed from younger patients in a greater reliability of effect and significantly shorter induction time. In elderly patients midazolam is a more reliable induction agent than in the young.

Original languageEnglish (US)
Pages (from-to)441-443
Number of pages3
JournalAnaesthesia
Volume40
Issue number5
DOIs
StatePublished - May 1985

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Keywords

  • Hypnotics, benzodiazepines; midazolam

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

DUNDEE, J. W., HALLIDAY, N. J., LOUGHRAN, P. G., & HARPER, K. W. (1985). The influence of age on the onset of anaesthesia with midazolam. Anaesthesia, 40(5), 441-443. https://doi.org/10.1111/j.1365-2044.1985.tb10845.x