The Infant of the Diabetic Mother: Correlation of Increased Cord C-Peptide Levels with Macrosomia and Hypoglycemia

Ilene R. Sosenko, John L. Kitzmiller, Sherry W. Loo, Petra Blix, Arthur H. Rubenstein, Kenneth H. Gabbay

Research output: Contribution to journalArticle

95 Scopus citations


C peptide is secreted by pancreatic beta cells in amounts equimolar with insulin, and its levels provide a direct indication of endogenous fetal levels of insulin despite the presence of maternal insulin antibodies. To determine the presence of hyperinsulinemia and its relation to the development of complications in infants of diabetic mothers, we measured cord serum levels of C peptide in 79 infants of diabetic mothers and 62 infants of nondiabetic mothers. Infants of diabetic mothers had higher cord levels of C peptide, which were significantly associated with neonatal hypoglycemia and macrosomia (P<0.001) but not with hyaline-membrane disease. Cord levels of C peptide in infants of diabetic mothers were elevated at the earliest gestational age studied (<34 weeks) and were directly related to the severity of maternal diabetes, as assessed by the White classification. We conclude that hyperinsulinemia is present in infants of diabetic mothers and that it is related to some major complications in such infants.

Original languageEnglish (US)
Pages (from-to)859-862
Number of pages4
JournalNew England Journal of Medicine
Issue number16
StatePublished - Oct 18 1979


ASJC Scopus subject areas

  • Medicine(all)

Cite this