TY - JOUR
T1 - The importance of wound biopsy in the accurate diagnosis of acral malignant melanoma presenting as a foot ulcer
AU - Yin, Natalie C.
AU - Miteva, Mariya
AU - Covington, Donald S.
AU - Romanelli, Paolo
AU - Stojadinovic, Olivera
PY - 2013/12
Y1 - 2013/12
N2 - Neoplastic changes arising at the sites of chronic, nonhealing wounds are not uncommon; however, they often go undiagnosed. We report a case of rapidly progressing plantar melanoma presenting as a chronic, nonhealing ulcer. A 46-year-old patient presented at a specialized Wound Healing Center with an enlarging painful ulcer on the right heel of 3 months duration. The wound was biopsied and specimens were sent for examination at the Wound Pathology service at the Department of Dermatology and Cutaneous Surgery, University of Miami. Histology demonstrated features consistent with acral malignant melanoma. Immunohistochemistry using melanocytic markers MART-1, S-100, HMB-45 revealed positive staining indicating the presence of malignant cells, and D2-40 staining showed lymphatic invasion of the tumor in the wound biopsy specimen. The case presented here underscores the importance of wound biopsying in the diagnosis of malignancies associated with nonhealing wounds.
AB - Neoplastic changes arising at the sites of chronic, nonhealing wounds are not uncommon; however, they often go undiagnosed. We report a case of rapidly progressing plantar melanoma presenting as a chronic, nonhealing ulcer. A 46-year-old patient presented at a specialized Wound Healing Center with an enlarging painful ulcer on the right heel of 3 months duration. The wound was biopsied and specimens were sent for examination at the Wound Pathology service at the Department of Dermatology and Cutaneous Surgery, University of Miami. Histology demonstrated features consistent with acral malignant melanoma. Immunohistochemistry using melanocytic markers MART-1, S-100, HMB-45 revealed positive staining indicating the presence of malignant cells, and D2-40 staining showed lymphatic invasion of the tumor in the wound biopsy specimen. The case presented here underscores the importance of wound biopsying in the diagnosis of malignancies associated with nonhealing wounds.
KW - biopsy
KW - foot
KW - malignant melanoma
KW - ulcer
KW - wound
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U2 - 10.1177/1534734613512505
DO - 10.1177/1534734613512505
M3 - Article
C2 - 24323391
AN - SCOPUS:84890949007
VL - 12
SP - 289
EP - 292
JO - International Journal of Lower Extremity Wounds
JF - International Journal of Lower Extremity Wounds
SN - 1534-7346
IS - 4
ER -