Abstract
Three factors were identified in a multivariate analysis of prognostic factors in men with metastatic prostate cancer as significantly associated with their progression-free survival: 1) extent of disease on the bone scan, 2) pretreatment serum testosterone, and 3) performance status. Men with less than six bone metastases, a pretreatment testosterone > 300 ng/100 ml, and an excellent performance status will have a progression-free survival much longer than a man with more extensive bone metastases, a low testosterone prior to androgen deprivation, and a poor performance status. This information should be used to ensure proper stratification in randomized trials. It may also be helpful in identifying the patient unlikely to be helped by our current treatment. Such patient should be considered for alternative approaches with the aim of improving survival.
| Original language | English |
|---|---|
| Pages (from-to) | 1017-1021 |
| Number of pages | 5 |
| Journal | Cancer |
| Volume | 66 |
| Issue number | 5 SUPPL. |
| State | Published - Jan 1 1990 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
The importance of prognostic factors in advanced prostate cancer. / Soloway, M. S.
In: Cancer, Vol. 66, No. 5 SUPPL., 01.01.1990, p. 1017-1021.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The importance of prognostic factors in advanced prostate cancer
AU - Soloway, M. S.
PY - 1990/1/1
Y1 - 1990/1/1
N2 - Three factors were identified in a multivariate analysis of prognostic factors in men with metastatic prostate cancer as significantly associated with their progression-free survival: 1) extent of disease on the bone scan, 2) pretreatment serum testosterone, and 3) performance status. Men with less than six bone metastases, a pretreatment testosterone > 300 ng/100 ml, and an excellent performance status will have a progression-free survival much longer than a man with more extensive bone metastases, a low testosterone prior to androgen deprivation, and a poor performance status. This information should be used to ensure proper stratification in randomized trials. It may also be helpful in identifying the patient unlikely to be helped by our current treatment. Such patient should be considered for alternative approaches with the aim of improving survival.
AB - Three factors were identified in a multivariate analysis of prognostic factors in men with metastatic prostate cancer as significantly associated with their progression-free survival: 1) extent of disease on the bone scan, 2) pretreatment serum testosterone, and 3) performance status. Men with less than six bone metastases, a pretreatment testosterone > 300 ng/100 ml, and an excellent performance status will have a progression-free survival much longer than a man with more extensive bone metastases, a low testosterone prior to androgen deprivation, and a poor performance status. This information should be used to ensure proper stratification in randomized trials. It may also be helpful in identifying the patient unlikely to be helped by our current treatment. Such patient should be considered for alternative approaches with the aim of improving survival.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024996407&partnerID=8YFLogxK
M3 - Article
C2 - 2393845
AN - SCOPUS:0024996407
VL - 66
SP - 1017
EP - 1021
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 5 SUPPL.
ER -