The Importance of Melanocortin Receptors and Their Agonists in Pulmonary Disease

Anna Elizabeth Moscowitz, Huda Asif, Laurence Baily Lindenmaier, Andrew Calzadilla, Chongxu Zhang, Mehdi Mirsaeidi

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Melanocortin agonists are ancient neuropeptides that have steroidogenesis and anti-inflammatory properties. They activate melanocortin receptors (MCR), a family of five seven-transmembrane G-protein coupled receptors. MC1R and MC3R are mainly involved in immunomodulatory effects. Adrenocorticotropin hormone (ACTH) and alpha-Melanocortin stimulating hormone (α-MSH) reduce pro-inflammatory cytokines in several pulmonary inflammatory disorders including asthma, sarcoidosis, and the acute respiratory distress syndrome. They have also been shown to reduce fibrogenesis in animal models with pulmonary fibrosis. By understanding the functions of MCR in macrophages, T-helper cell type 1, and T-helper cell type 17, we may uncover the mechanism of action of melanocortin agonists in sarcoidosis. Further translational and clinical research is needed to define the role of ACTH and α-MSH in pulmonary diseases.

Original languageEnglish (US)
Article number145
JournalFrontiers in Medicine
Volume6
DOIs
StatePublished - Jun 27 2019

Keywords

  • ACTH
  • MCR
  • melanocortin
  • sarcoidosis
  • α-MSH

ASJC Scopus subject areas

  • Medicine(all)

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