The importance of caveolins and caveolae to dermatology: Lessons from the caves and beyond

Andjela N. Egger, Ali Rajabiestarabadi, Natalie M. Williams, Sydney R. Resnik, Joshua D. Fox, Lulu L. Wong, Ivan Jozic

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Caveolae are flask-shaped invaginations of the cell membrane rich in cholesterol and sphingomyelin, with caveolin proteins acting as their primary structural components that allow compartmentalization and orchestration of various signalling molecules. In this review, we discuss how pleiotropic functions of caveolin-1 (Cav1) and its intricate roles in numerous cellular functions including lipid trafficking, signalling, cell migration and proliferation, as well as cellular senescence, infection and inflammation, are integral for normal development and functioning of skin and its appendages. We then examine how disruption of the homeostatic levels of Cav1 can lead to development of various cutaneous pathophysiologies including skin cancers, cutaneous fibroses, psoriasis, alopecia, age-related changes in skin and aberrant wound healing and propose how levels of Cav1 may have theragnostic value in skin physiology/pathophysiology.

Original languageEnglish (US)
Pages (from-to)136-148
Number of pages13
JournalExperimental dermatology
Volume29
Issue number2
DOIs
StatePublished - Feb 1 2020

Keywords

  • caveolae
  • caveolin-1
  • fibrosis
  • melanoma
  • psoriasis
  • squamous cell carcinoma
  • wound healing

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

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