The impact of pregnancy and childbirth on the metabolism of lamotrigine

P. B. Pennell, D. J. Newport, Z. N. Stowe, S. L. Helmers, J. Q. Montgomery, T. R. Henry

Research output: Contribution to journalArticlepeer-review

175 Scopus citations


This study was performed to clarify alterations in lamotrigine (LTG) clearance during pregnancy and childbirth. Fourteen women on LTG monotherapy had LTG concentration samples obtained before conception and monthly. LTG apparent clearance, weight-adjusted relative clearance, and percentages of baseline clearance significantly differed between preconception baseline and each trimester and between trimesters. LTG clearance progressively increased until 32 weeks' gestational age, reaching a peak of >330% of baseline, and then began to decline.

Original languageEnglish (US)
Pages (from-to)292-295
Number of pages4
Issue number2
StatePublished - Jan 27 2004
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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