The impact of donor cocaine use on the outcome of adult liver transplantation

Teruo Komokata, Seigo Nishida, Susan Ganz, David M. Levi, Tatuya Fukumori, Andreas G. Tzakis

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Backgrounds: To investigate the feasibility of adult liver transplantation from donors with cocaine use. Methods: Of 807 adult liver transplantations performed between 1994 and 2000, 72 donors (8.9%) were current cocaine users. Donor characteristics and post-transplantation outcomes were retrospectively compared between the 72 cocaine and 126 control group selected from the remaining 735 donors, matched for age and having no history of drug use. Results: Marijuana, opiates and amphetamines were drugs of abuse often present with cocaine. Except for a high incidence of acute alcohol use in the cocaine donors, donor characteristics were comparable. The cocaine group had a significantly higher graft loss within three months of transplant (18.1% vs. 7.9%, p<0.05), and had a trend toward lower graft survival (76% vs. 86% at one yr). Conclusions: Potential adverse effect of cocaine and substances concurrently involved on donor liver was suggested. To clarify the distinct acceptance criteria of cocaine users for liver donation, prospective study is warranted.

Original languageEnglish (US)
Pages (from-to)295-300
Number of pages6
JournalClinical Transplantation
Volume20
Issue number3
DOIs
StatePublished - May 1 2006

Keywords

  • Cocaine
  • Liver transplantation
  • Marginal donor

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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    Komokata, T., Nishida, S., Ganz, S., Levi, D. M., Fukumori, T., & Tzakis, A. G. (2006). The impact of donor cocaine use on the outcome of adult liver transplantation. Clinical Transplantation, 20(3), 295-300. https://doi.org/10.1111/j.1399-0012.2006.00481.x