The impact of caspase-12 on susceptibility to candidemia

D. C. Rosentul, T. S. Plantinga, W. K. Scott, B. D. Alexander, N. M.D. Van De Geer, J. R. Perfect, B. J. Kullberg, M. D. Johnson, M. G. Netea

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Candida is one of the leading causes of sepsis, and an effective host immune response to Candida critically depends on the cytokines IL-1β and IL-18, which need caspase-1 cleavage to become bioactive. Caspase-12 has been suggested to inhibit caspase-1 activation and has been implicated as a susceptibility factor for bacterial sepsis. In populations of African descent, CASPASE-12 is either functional or non-functional. Here, we have assessed the frequencies of both CASPASE-12 alleles in an African-American Candida sepsis patients cohort compared to uninfected patients with similar predisposing factors. African-American Candida sepsis patients (n∈=∈93) and non-infected African-American patients (n∈=∈88) were genotyped for the CASPASE-12 genotype. Serum cytokine concentrations of IL-6, IL-8, and IFNγ were measured in the serum of infected patients. Statistical comparisons were performed in order to assess the effect of the CASPASE-12 genotype on susceptibility to candidemia and on serum cytokine concentrations. Our findings demonstrate that CASPASE-12 does not influence the susceptibility to Candida sepsis, nor has any effect on the serum cytokine concentrations in Candida sepsis patients during the course of infection. Although the functional CASPASE-12 allele has been suggested to increase susceptibility to bacterial sepsis, this could not be confirmed in our larger cohort of fungal sepsis patients.

Original languageEnglish (US)
Pages (from-to)277-280
Number of pages4
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume31
Issue number3
DOIs
StatePublished - Mar 2012

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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