The immunological identity of tumor: Self implications

Jason Miska, Priyadharshini Devarajan, Zhibin Chen

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

By means of well-characterized autoimmunity models, we comparatively probed the "selfness" of malignant cells and their normal counterparts. We found that tumors activate self-tolerance mechanisms much more efficiently than normal tissues, reflecting a status of immunoprivileged "self." Our findings indicate that potent autoimmune responses can eradicate established malignancies, yet the collateral destruction of healthy tissues may prove difficult to circumvent.

Original languageEnglish (US)
Article numbere23794
JournalOncoImmunology
Volume2
Issue number4
DOIs
StatePublished - Apr 1 2013

Keywords

  • Altered self
  • Autoimmunity
  • Cancer
  • Immunoprivileged self
  • Regulatory T cell (Treg)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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