The immunological identity of tumor: Self implications

Jason Miska, Priyadharshini Devarajan, Zhibin Chen

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


By means of well-characterized autoimmunity models, we comparatively probed the "selfness" of malignant cells and their normal counterparts. We found that tumors activate self-tolerance mechanisms much more efficiently than normal tissues, reflecting a status of immunoprivileged "self." Our findings indicate that potent autoimmune responses can eradicate established malignancies, yet the collateral destruction of healthy tissues may prove difficult to circumvent.

Original languageEnglish (US)
Article numbere23794
Issue number4
StatePublished - Apr 2013


  • Altered self
  • Autoimmunity
  • Cancer
  • Immunoprivileged self
  • Regulatory T cell (Treg)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology


Dive into the research topics of 'The immunological identity of tumor: Self implications'. Together they form a unique fingerprint.

Cite this