The immunologic effects, kinetics, and use of glucocorticosteroids

J. Meuleman, P. Katz

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Few therapeutic agents are as effective in such a variety of clinical situations as the glucocorticosteroids. Beginning with their first use over 30 years ago in the treatment of rheumatoid arthritis, they have proved to be a group of drugs with potent effects on many aspects of the immune system. Studies in the past 10 years have begun to shed light on the mechanisms of these effects, yet the precise means of benefit in individual immune disorders continues to elude us. This article describes our current understanding of the immunologic effects of glucocorticosteroids and uses this information in an attempt to place the therapeutic dosing of glucocorticosteroids on a more rational basis. The important topics of the side effects of glucocorticosteroids or their use in individual disease states will not be covered.

Original languageEnglish
Pages (from-to)805-816
Number of pages12
JournalMedical Clinics of North America
Volume69
Issue number4
StatePublished - Dec 1 1985
Externally publishedYes

Fingerprint

Immune System Diseases
Immune System
Rheumatoid Arthritis
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The immunologic effects, kinetics, and use of glucocorticosteroids. / Meuleman, J.; Katz, P.

In: Medical Clinics of North America, Vol. 69, No. 4, 01.12.1985, p. 805-816.

Research output: Contribution to journalArticle

Meuleman, J. ; Katz, P. / The immunologic effects, kinetics, and use of glucocorticosteroids. In: Medical Clinics of North America. 1985 ; Vol. 69, No. 4. pp. 805-816.
@article{7d8cec374bb144019e0b172f535d5065,
title = "The immunologic effects, kinetics, and use of glucocorticosteroids",
abstract = "Few therapeutic agents are as effective in such a variety of clinical situations as the glucocorticosteroids. Beginning with their first use over 30 years ago in the treatment of rheumatoid arthritis, they have proved to be a group of drugs with potent effects on many aspects of the immune system. Studies in the past 10 years have begun to shed light on the mechanisms of these effects, yet the precise means of benefit in individual immune disorders continues to elude us. This article describes our current understanding of the immunologic effects of glucocorticosteroids and uses this information in an attempt to place the therapeutic dosing of glucocorticosteroids on a more rational basis. The important topics of the side effects of glucocorticosteroids or their use in individual disease states will not be covered.",
author = "J. Meuleman and P. Katz",
year = "1985",
month = "12",
day = "1",
language = "English",
volume = "69",
pages = "805--816",
journal = "Medical Clinics of North America",
issn = "0025-7125",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - The immunologic effects, kinetics, and use of glucocorticosteroids

AU - Meuleman, J.

AU - Katz, P.

PY - 1985/12/1

Y1 - 1985/12/1

N2 - Few therapeutic agents are as effective in such a variety of clinical situations as the glucocorticosteroids. Beginning with their first use over 30 years ago in the treatment of rheumatoid arthritis, they have proved to be a group of drugs with potent effects on many aspects of the immune system. Studies in the past 10 years have begun to shed light on the mechanisms of these effects, yet the precise means of benefit in individual immune disorders continues to elude us. This article describes our current understanding of the immunologic effects of glucocorticosteroids and uses this information in an attempt to place the therapeutic dosing of glucocorticosteroids on a more rational basis. The important topics of the side effects of glucocorticosteroids or their use in individual disease states will not be covered.

AB - Few therapeutic agents are as effective in such a variety of clinical situations as the glucocorticosteroids. Beginning with their first use over 30 years ago in the treatment of rheumatoid arthritis, they have proved to be a group of drugs with potent effects on many aspects of the immune system. Studies in the past 10 years have begun to shed light on the mechanisms of these effects, yet the precise means of benefit in individual immune disorders continues to elude us. This article describes our current understanding of the immunologic effects of glucocorticosteroids and uses this information in an attempt to place the therapeutic dosing of glucocorticosteroids on a more rational basis. The important topics of the side effects of glucocorticosteroids or their use in individual disease states will not be covered.

UR - http://www.scopus.com/inward/record.url?scp=0022373729&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022373729&partnerID=8YFLogxK

M3 - Article

C2 - 2997555

AN - SCOPUS:0022373729

VL - 69

SP - 805

EP - 816

JO - Medical Clinics of North America

JF - Medical Clinics of North America

SN - 0025-7125

IS - 4

ER -