The immune boundaries for stem cell based therapies: Problems and prospective solutions

Abdelkrim Hmadcha; Juan Domínguez-Bendala; Jane Wakeman; Mohamed Arredouani; Bernat Soria

doi:10.1111/j.1582-4934.2009.00837.x

The immune boundaries for stem cell based therapies: Problems and prospective solutions

Abdelkrim Hmadcha, Juan Domínguez-Bendala, Jane Wakeman, Mohamed Arredouani, Bernat Soria

Surgery

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Stem cells have fascinated the scientific and clinical communities for over a century. Despite the controversy that surrounds this field, it is clear that stem cells have the potential to revolutionize medicine. However, a number of significant hurdles still stand in the way of the realization of this potential. Chiefly among these are safety concerns, differentiation efficiency and overcoming immune rejection. Here we review current progress made in this field to optimize the safe use of stem cells with particular emphasis on prospective interventions to deal with challenges generated by immune rejection.

Original language	English (US)
Pages (from-to)	1464-1475
Number of pages	12
Journal	Journal of Cellular and Molecular Medicine
Volume	13
Issue number	8 A
DOIs	https://doi.org/10.1111/j.1582-4934.2009.00837.x
State	Published - Aug 2009

Keywords

Cell therapies
Histocompatibility
Immune rejection
Stem cells

ASJC Scopus subject areas

Cell Biology
Molecular Medicine

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