Abstract
Stem cells have fascinated the scientific and clinical communities for over a century. Despite the controversy that surrounds this field, it is clear that stem cells have the potential to revolutionize medicine. However, a number of significant hurdles still stand in the way of the realization of this potential. Chiefly among these are safety concerns, differentiation efficiency and overcoming immune rejection. Here we review current progress made in this field to optimize the safe use of stem cells with particular emphasis on prospective interventions to deal with challenges generated by immune rejection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1464-1475 |
| Number of pages | 12 |
| Journal | Journal of Cellular and Molecular Medicine |
| Volume | 13 |
| Issue number | 8 A |
| DOIs | |
| State | Published - Aug 1 2009 |
Keywords
- Cell therapies
- Histocompatibility
- Immune rejection
- Stem cells
ASJC Scopus subject areas
- Cell Biology
- Molecular Medicine
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Cite this
Hmadcha, A., Domínguez-Bendala, J., Wakeman, J., Arredouani, M., & Soria, B. (2009). The immune boundaries for stem cell based therapies: Problems and prospective solutions. Journal of Cellular and Molecular Medicine, 13(8 A), 1464-1475. https://doi.org/10.1111/j.1582-4934.2009.00837.x