The immune boundaries for stem cell based therapies: Problems and prospective solutions

Abdelkrim Hmadcha, Juan Domínguez-Bendala, Jane Wakeman, Mohamed Arredouani, Bernat Soria

Research output: Contribution to journalArticle

15 Scopus citations


Stem cells have fascinated the scientific and clinical communities for over a century. Despite the controversy that surrounds this field, it is clear that stem cells have the potential to revolutionize medicine. However, a number of significant hurdles still stand in the way of the realization of this potential. Chiefly among these are safety concerns, differentiation efficiency and overcoming immune rejection. Here we review current progress made in this field to optimize the safe use of stem cells with particular emphasis on prospective interventions to deal with challenges generated by immune rejection.

Original languageEnglish (US)
Pages (from-to)1464-1475
Number of pages12
JournalJournal of Cellular and Molecular Medicine
Issue number8 A
StatePublished - Aug 1 2009



  • Cell therapies
  • Histocompatibility
  • Immune rejection
  • Stem cells

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine

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