The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection

Alejandro Villarino, Linda Hibbert, Linda Lieberman, Emma Wilson, Tak Mak, Hiroki Yoshida, Robert A. Kastelein, Christiaan Saris, Christopher A. Hunter

Research output: Contribution to journalArticlepeer-review

380 Scopus citations

Abstract

Although recent studies have described IL-27 and its receptor, WSX-1, as promoters of Th1 differentiation in naive CD4+ T cells, the data presented here indicate that signaling through this receptor is involved in limiting the intensity and duration of T cell activity. When WSX-1-deficient mice are infected with the intracellular pathogen Toxoplasma gondii, they establish protective T cell responses, characterized by production of inflammatory cytokines and control of parasite replication. However, infected WSX-1-/- mice are unable to downregulate these protective responses, and develop a lethal, T cell-mediated inflammatory disease. This pathology was characterized by the excessive production of IFN-γ, persistence of highly activated T cells, and enhanced T cell proliferation in vivo. Together, these findings demonstrate that WSX-1 is not required for the generation of IFN-γ-mediated immunity to this parasitic infection and identify a novel function for this receptor as a potent antagonist of T cell-mediated, immune hyperactivity.

Original languageEnglish (US)
Pages (from-to)645-655
Number of pages11
JournalImmunity
Volume19
Issue number5
DOIs
StatePublished - Nov 2003
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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