The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity

David Artis, Alejandro Villarino, Michael Silverman, Weimian He, Elizabeth M. Thornton, Sharon Mu, Shamin Summer, Todd M. Covey, Elaine Huang, Hiroki Yoshida, Gary Koretzky, Michael Goldschmidt, Gary D. Wu, Fred De Sauvage, Hugh R.P. Miller, Christiaan J.M. Saris, Phillip Scott, Christopher A. Hunter

Research output: Contribution to journalArticlepeer-review

199 Scopus citations

Abstract

Although previous studies have investigated the role of IL-27/WSX-1 interactions in the regulation of Th1 responses, little is known about their role in regulating Th2-type responses. Studies presented in this work identify a direct role for IL-27/WSX-1 interactions in the negative regulation of type 2 responses independent of effects on type 1 cytokines. WSX-1-/- mice infected with the gastrointestinal helminth Trichuris muris displayed accelerated expulsion of parasites and the development of exaggerated goblet cell hyperplasia and mastocytosis in the gut due to increased production of Th2 cytokines. Enhanced mast cell activity in the absence of WSX-1 was consistent with the ability of wild-type mast cells to express this receptor. In addition, EL-27 directly suppressed CD4+ T cell proliferation and Th2 cytokine production. Together, these studies identify a novel role for IL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites.

Original languageEnglish (US)
Pages (from-to)5626-5634
Number of pages9
JournalJournal of Immunology
Volume173
Issue number9
DOIs
StatePublished - Nov 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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