TY - JOUR
T1 - The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity
AU - Artis, David
AU - Villarino, Alejandro
AU - Silverman, Michael
AU - He, Weimian
AU - Thornton, Elizabeth M.
AU - Mu, Sharon
AU - Summer, Shamin
AU - Covey, Todd M.
AU - Huang, Elaine
AU - Yoshida, Hiroki
AU - Koretzky, Gary
AU - Goldschmidt, Michael
AU - Wu, Gary D.
AU - De Sauvage, Fred
AU - Miller, Hugh R.P.
AU - Saris, Christiaan J.M.
AU - Scott, Phillip
AU - Hunter, Christopher A.
PY - 2004/11/1
Y1 - 2004/11/1
N2 - Although previous studies have investigated the role of IL-27/WSX-1 interactions in the regulation of Th1 responses, little is known about their role in regulating Th2-type responses. Studies presented in this work identify a direct role for IL-27/WSX-1 interactions in the negative regulation of type 2 responses independent of effects on type 1 cytokines. WSX-1-/- mice infected with the gastrointestinal helminth Trichuris muris displayed accelerated expulsion of parasites and the development of exaggerated goblet cell hyperplasia and mastocytosis in the gut due to increased production of Th2 cytokines. Enhanced mast cell activity in the absence of WSX-1 was consistent with the ability of wild-type mast cells to express this receptor. In addition, EL-27 directly suppressed CD4+ T cell proliferation and Th2 cytokine production. Together, these studies identify a novel role for IL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites.
AB - Although previous studies have investigated the role of IL-27/WSX-1 interactions in the regulation of Th1 responses, little is known about their role in regulating Th2-type responses. Studies presented in this work identify a direct role for IL-27/WSX-1 interactions in the negative regulation of type 2 responses independent of effects on type 1 cytokines. WSX-1-/- mice infected with the gastrointestinal helminth Trichuris muris displayed accelerated expulsion of parasites and the development of exaggerated goblet cell hyperplasia and mastocytosis in the gut due to increased production of Th2 cytokines. Enhanced mast cell activity in the absence of WSX-1 was consistent with the ability of wild-type mast cells to express this receptor. In addition, EL-27 directly suppressed CD4+ T cell proliferation and Th2 cytokine production. Together, these studies identify a novel role for IL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites.
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U2 - 10.4049/jimmunol.173.9.5626
DO - 10.4049/jimmunol.173.9.5626
M3 - Article
C2 - 15494513
AN - SCOPUS:6344274850
VL - 173
SP - 5626
EP - 5634
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 9
ER -