The IL-2 receptor γc chain does not function as a subunit shared by the IL-4 and IL-13 receptors: Implication for the structure of the IL-4 receptor

You Wen He, Thomas Malek

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The IL-2 receptor (IL-2R) γc subunit is also a component of the receptors for IL-4, IL-7, IL-9, and IL-15. The IL-4R and IL-13R appear to share a common subunit, and γc was proposed to be this shared subunit. In this study, we have assessed the relative contribution of γc to the mouse IL-4R and IL-13R. The MC/9 mast cell line constitutively expresses γc and proliferates to IL-4 and IL-13, but only the response to IL-4 was blocked by anti-γc mAbs. After transfection of the IL-4- and IL-13-responsive γc-negative B9 plasmacytoma with full length (my) or cytoplasmic-tailless γc cDNA (mγt), only the proliferative response to IL-4 was affected by the surface expression of these γc molecules. The inability of mγ or mγt expression to affect IL-13-induced proliferation by B9 indicates that γc does not obviously contribute to the IL-13R and does not function as the shared subunit of the IL-4R and IL-13R. This study suggests that there are two dis-tinct IL-4R, one of which is independent of γc.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalJournal of Immunology
Issue number1
StatePublished - Dec 1 1995


ASJC Scopus subject areas

  • Immunology

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