The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide

Jan Bøler; Franz Enzmann; K. Folkers; C. Y. Bowers; A. V. Schally

doi:10.1016/0006-291X(69)90868-7

The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide

Jan Bøler, Franz Enzmann, K. Folkers, C. Y. Bowers, A. V. Schally

Research output: Contribution to journal › Article › peer-review

424 Scopus citations

Abstract

The structure of L-pyroglutamyl-l-histidyl-l-proline amide (I) is in agreement with all Qf the known chemical and hormonal properties of the thyrotropin releasing hormone (TIM) from porcine hypothalami. This structural interpretation is probably applicable to the THE of other mammalian species, and is chemically based on the chromatographic identity in seventeen diversified systems and is biologically based on a quantitative comparison of the hormonal activities of the natural and synthetic products. This formulation of structure represents the elucidation of the first of the hypothalamic hormones that have been sought for so long.

Original language	English (US)
Pages (from-to)	705-710
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	37
Issue number	4
DOIs	https://doi.org/10.1016/0006-291X(69)90868-7
State	Published - Nov 6 1969
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1016/0006-291X(69)90868-7

Cite this

@article{8b0622c7a40444a6b4ef89489ced7621,

title = "The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide",

abstract = "The structure of L-pyroglutamyl-l-histidyl-l-proline amide (I) is in agreement with all Qf the known chemical and hormonal properties of the thyrotropin releasing hormone (TIM) from porcine hypothalami. This structural interpretation is probably applicable to the THE of other mammalian species, and is chemically based on the chromatographic identity in seventeen diversified systems and is biologically based on a quantitative comparison of the hormonal activities of the natural and synthetic products. This formulation of structure represents the elucidation of the first of the hypothalamic hormones that have been sought for so long.",

author = "Jan B{\o}ler and Franz Enzmann and K. Folkers and Bowers, {C. Y.} and Schally, {A. V.}",

year = "1969",

month = nov,

day = "6",

doi = "10.1016/0006-291X(69)90868-7",

language = "English (US)",

volume = "37",

pages = "705--710",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "4",

}

TY - JOUR

T1 - The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide

AU - Bøler, Jan

AU - Enzmann, Franz

AU - Folkers, K.

AU - Bowers, C. Y.

AU - Schally, A. V.

PY - 1969/11/6

Y1 - 1969/11/6

N2 - The structure of L-pyroglutamyl-l-histidyl-l-proline amide (I) is in agreement with all Qf the known chemical and hormonal properties of the thyrotropin releasing hormone (TIM) from porcine hypothalami. This structural interpretation is probably applicable to the THE of other mammalian species, and is chemically based on the chromatographic identity in seventeen diversified systems and is biologically based on a quantitative comparison of the hormonal activities of the natural and synthetic products. This formulation of structure represents the elucidation of the first of the hypothalamic hormones that have been sought for so long.

AB - The structure of L-pyroglutamyl-l-histidyl-l-proline amide (I) is in agreement with all Qf the known chemical and hormonal properties of the thyrotropin releasing hormone (TIM) from porcine hypothalami. This structural interpretation is probably applicable to the THE of other mammalian species, and is chemically based on the chromatographic identity in seventeen diversified systems and is biologically based on a quantitative comparison of the hormonal activities of the natural and synthetic products. This formulation of structure represents the elucidation of the first of the hypothalamic hormones that have been sought for so long.

UR - http://www.scopus.com/inward/record.url?scp=0014666196&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014666196&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(69)90868-7

DO - 10.1016/0006-291X(69)90868-7

M3 - Article

C2 - 4982117

AN - SCOPUS:0014666196

VL - 37

SP - 705

EP - 710

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 4

ER -

The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this