The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide

Jan Bøler; Franz Enzmann; K. Folkers; C. Y. Bowers; A. V. Schally

doi:10.1016/0006-291X(69)90868-7

The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide

Jan Bøler, Franz Enzmann, K. Folkers, C. Y. Bowers, A. V. Schally

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397 Scopus citations

Abstract

The structure of L-pyroglutamyl-l-histidyl-l-proline amide (I) is in agreement with all Qf the known chemical and hormonal properties of the thyrotropin releasing hormone (TIM) from porcine hypothalami. This structural interpretation is probably applicable to the THE of other mammalian species, and is chemically based on the chromatographic identity in seventeen diversified systems and is biologically based on a quantitative comparison of the hormonal activities of the natural and synthetic products. This formulation of structure represents the elucidation of the first of the hypothalamic hormones that have been sought for so long.

Original language	English (US)
Pages (from-to)	705-710
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	37
Issue number	4
DOIs	https://doi.org/10.1016/0006-291X(69)90868-7
State	Published - Nov 6 1969
Externally published	Yes

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ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Bøler, J., Enzmann, F., Folkers, K., Bowers, C. Y., & Schally, A. V. (1969). The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide. Biochemical and biophysical research communications, 37(4), 705-710. https://doi.org/10.1016/0006-291X(69)90868-7

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10.1016/0006-291X(69)90868-7