The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide

Jan Bøler, Franz Enzmann, K. Folkers, C. Y. Bowers, A. V. Schally

Research output: Contribution to journalArticle

401 Scopus citations

Abstract

The structure of L-pyroglutamyl-l-histidyl-l-proline amide (I) is in agreement with all Qf the known chemical and hormonal properties of the thyrotropin releasing hormone (TIM) from porcine hypothalami. This structural interpretation is probably applicable to the THE of other mammalian species, and is chemically based on the chromatographic identity in seventeen diversified systems and is biologically based on a quantitative comparison of the hormonal activities of the natural and synthetic products. This formulation of structure represents the elucidation of the first of the hypothalamic hormones that have been sought for so long.

Original languageEnglish (US)
Pages (from-to)705-710
Number of pages6
JournalBiochemical and biophysical research communications
Volume37
Issue number4
DOIs
StatePublished - Nov 6 1969
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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