The human mitochondrial genome: Mechanisms of expression and maintenance

Jan Willem Taanman, Siôn Llewelyn Williams

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations


Mitochondria are essential eukaryotic organelles whose principal function is to generate ATP through the process of oxidative phosphorylation(1). They also house many additional metabolic pathways and are involved inCa2+ homeostasis, apoptosis, and thermogenesis (2-4). Mitochondria possess two membranes: an outer membrane, which encloses the organelle and separates it from the cytosol, and a larger inner membrane. The latter can be further divided into two contiguous components: the inner boundary membrane that apposes the outer membrane, and the cristae membrane that projects into the matrix compartment (5,6). The five multisubunit complexes (I through V) of the oxidative phosphorylation system required for ATP synthesis are embedded in the cristae membrane (7).

Original languageEnglish (US)
Title of host publicationMitochondria in Health and Disease
PublisherCRC Press
Number of pages152
ISBN (Electronic)9781420028843
ISBN (Print)0824754425, 9780824754426
StatePublished - Jan 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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