The human mitochondrial genome

Mechanisms of expression and maintenance

Jan Willem Taanman, Sion Llewelyn Williams

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Mitochondria are essential eukaryotic organelles whose principal function is to generate ATP through the process of oxidative phosphorylation(1). They also house many additional metabolic pathways and are involved inCa2+ homeostasis, apoptosis, and thermogenesis (2-4). Mitochondria possess two membranes: an outer membrane, which encloses the organelle and separates it from the cytosol, and a larger inner membrane. The latter can be further divided into two contiguous components: the inner boundary membrane that apposes the outer membrane, and the cristae membrane that projects into the matrix compartment (5,6). The five multisubunit complexes (I through V) of the oxidative phosphorylation system required for ATP synthesis are embedded in the cristae membrane (7).

Original languageEnglish (US)
Title of host publicationMitochondria in Health and Disease
PublisherCRC Press
Pages95-246
Number of pages152
ISBN (Electronic)9781420028843
ISBN (Print)0824754425, 9780824754426
StatePublished - Jan 1 2005
Externally publishedYes

Fingerprint

Mitochondrial Genome
Human Genome
Genes
Maintenance
Membranes
Mitochondria
Oxidative Phosphorylation
Organelles
Adenosine Triphosphate
Thermogenesis
Metabolic Networks and Pathways
Cytosol
Homeostasis
Apoptosis

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Taanman, J. W., & Williams, S. L. (2005). The human mitochondrial genome: Mechanisms of expression and maintenance. In Mitochondria in Health and Disease (pp. 95-246). CRC Press.

The human mitochondrial genome : Mechanisms of expression and maintenance. / Taanman, Jan Willem; Williams, Sion Llewelyn.

Mitochondria in Health and Disease. CRC Press, 2005. p. 95-246.

Research output: Chapter in Book/Report/Conference proceedingChapter

Taanman, JW & Williams, SL 2005, The human mitochondrial genome: Mechanisms of expression and maintenance. in Mitochondria in Health and Disease. CRC Press, pp. 95-246.
Taanman JW, Williams SL. The human mitochondrial genome: Mechanisms of expression and maintenance. In Mitochondria in Health and Disease. CRC Press. 2005. p. 95-246
Taanman, Jan Willem ; Williams, Sion Llewelyn. / The human mitochondrial genome : Mechanisms of expression and maintenance. Mitochondria in Health and Disease. CRC Press, 2005. pp. 95-246
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