The human glycine receptor

A new probe that is linked to the X-linked hypophosphatemic rickets gene

M. J. Econs, Margaret A Pericak-Vance, H. Betz, R. J. Bartlett, M. C. Speer, M. K. Drezner

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We undertook linkage analysis in four large North Carolina kindreds with X-linked hypophosphatemic rickets (HYP) using a newly defined polymorphic probe, derived from the 5′ untranslated portion of the human glycine receptor (GLR). Two-point linkage analysis established linkage between GLR and HYP [Z(θ) = 7.91 at θ = 0.07] and confirmed linkage between HYP and DXS41 [Z(θ) = 8.31 at θ = 0.06] and DXS43 [Z(θ) = 5.94 at θ = 0.05]. Additionally, we found GLR tightly linked to DXS43 [Z(θ) = 5.40 at θ = 0.0]. Multipoint analysis indicated that GLR is on the telomeric side of HYP with a map order of Xpcen-DXS41-HYP-( GLR DXS43).

Original languageEnglish
Pages (from-to)439-441
Number of pages3
JournalGenomics
Volume7
Issue number3
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

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Familial Hypophosphatemic Rickets
Glycine Receptors
Hypophosphatemic Rickets
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

The human glycine receptor : A new probe that is linked to the X-linked hypophosphatemic rickets gene. / Econs, M. J.; Pericak-Vance, Margaret A; Betz, H.; Bartlett, R. J.; Speer, M. C.; Drezner, M. K.

In: Genomics, Vol. 7, No. 3, 01.01.1990, p. 439-441.

Research output: Contribution to journalArticle

Econs, M. J. ; Pericak-Vance, Margaret A ; Betz, H. ; Bartlett, R. J. ; Speer, M. C. ; Drezner, M. K. / The human glycine receptor : A new probe that is linked to the X-linked hypophosphatemic rickets gene. In: Genomics. 1990 ; Vol. 7, No. 3. pp. 439-441.
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