The hope for an HIV vaccine based on induction of CD8+ T lymphocytes - A Review

David I. Watkins

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


The only long-term and cost-effective solution to the human immunodeficiency virus (HIV) epidemic in the developing world is a vaccine that prevents individuals from becoming infected or, once infected, from passing the virus on to others. There is currently little hope for an AIDS vaccine. Conventional attempts to induce protective antibody and CD8+ lymphocyte responses against HIV and simian immunodeficiency virus (SIV) have failed. The enormous diversity of the virus has only recently been appreciated by vaccinologists, and our assays to determine CD8+ lymphocyte antiviral efficacy are inadequate. The central hypothesis of a CTL-based vaccine is that particularly effective CD8+ lymphocytes directed against at least five epitopes that are derived from regions under functional and structural constraints will control replication of pathogenic SIV. This would be somewhat analogous to control of virus replication by triple drug therapy or neutralizing antibodies.

Original languageEnglish (US)
Pages (from-to)119-129
Number of pages11
JournalMemorias do Instituto Oswaldo Cruz
Issue number2
StatePublished - Mar 2008
Externally publishedYes


  • CTL
  • HIV
  • SIV
  • Vaccines

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology
  • Immunology
  • Microbiology (medical)
  • Clinical Biochemistry


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