The hope for an HIV vaccine based on induction of CD8+ T lymphocytes - A Review

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The only long-term and cost-effective solution to the human immunodeficiency virus (HIV) epidemic in the developing world is a vaccine that prevents individuals from becoming infected or, once infected, from passing the virus on to others. There is currently little hope for an AIDS vaccine. Conventional attempts to induce protective antibody and CD8+ lymphocyte responses against HIV and simian immunodeficiency virus (SIV) have failed. The enormous diversity of the virus has only recently been appreciated by vaccinologists, and our assays to determine CD8+ lymphocyte antiviral efficacy are inadequate. The central hypothesis of a CTL-based vaccine is that particularly effective CD8+ lymphocytes directed against at least five epitopes that are derived from regions under functional and structural constraints will control replication of pathogenic SIV. This would be somewhat analogous to control of virus replication by triple drug therapy or neutralizing antibodies.

Original languageEnglish
Pages (from-to)119-129
Number of pages11
JournalMemorias do Instituto Oswaldo Cruz
Volume103
Issue number2
StatePublished - Mar 1 2008
Externally publishedYes

Fingerprint

T-cells
Viruses
Simian Immunodeficiency Virus
Vaccines
HIV
Lymphocytes
T-Lymphocytes
AIDS Vaccines
Virus Replication
Neutralizing Antibodies
Antiviral Agents
Epitopes
Costs and Cost Analysis
Drug Therapy
Antibodies
Drug therapy
Assays
Costs

Keywords

  • CTL
  • HIV
  • SIV
  • Vaccines

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology
  • Immunology
  • Microbiology (medical)
  • Clinical Biochemistry

Cite this

The hope for an HIV vaccine based on induction of CD8+ T lymphocytes - A Review. / Watkins, David.

In: Memorias do Instituto Oswaldo Cruz, Vol. 103, No. 2, 01.03.2008, p. 119-129.

Research output: Contribution to journalArticle

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