The HIV glycoprotein gp160 has superantigen-like properties

P. N. Akolkar, B. Gulwani-Akolkar, N. Chirmule, Savita G Pahwa, V. S. Kalyanaraman, R. Pergolizzi, S. MacPhail, J. Silver

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

HIV infection is characterized by paralysis of the immune system and a depletion of CD4+ cells. Recent studies demonstrating modulation of the Vβ T cell receptor (TCR) repertoire in HIV patients have suggested that some of these effects may be the result of action by one or more superantigens encoded by the virus. In order to determine whether the HIV envelope glycoprotein, gp160, displays properties reminiscent of a superantigen, the T cell receptor V,B repertoire of T cells from healthy, seronegative individuals activated in vitro with gp160 was determined. In five individuals of disparate HLA type, activation by gp160 resulted in a marked skewing in the relative expression of a common set of Vβ gene segments. This activation was HLA class II-dependent and did not require antigen processing. Surprisingly, the Vβ segments affected by gp160 bore a striking similarity to those affected by the staphylococcal superantigen SEB. These observations suggest that exposure to superantigens produced by opportunistic infection might play an important role in disease progression.

Original languageEnglish
Pages (from-to)255-265
Number of pages11
JournalClinical Immunology and Immunopathology
Volume76
Issue number3 I
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

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HIV Envelope Protein gp160
Superantigens
Glycoproteins
T-Cell Antigen Receptor
Opportunistic Infections
Antigen Presentation
Paralysis
HIV Infections
Disease Progression
Immune System
HIV
Viruses
T-Lymphocytes
Genes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Akolkar, P. N., Gulwani-Akolkar, B., Chirmule, N., Pahwa, S. G., Kalyanaraman, V. S., Pergolizzi, R., ... Silver, J. (1995). The HIV glycoprotein gp160 has superantigen-like properties. Clinical Immunology and Immunopathology, 76(3 I), 255-265. https://doi.org/10.1006/clin.1995.1124

The HIV glycoprotein gp160 has superantigen-like properties. / Akolkar, P. N.; Gulwani-Akolkar, B.; Chirmule, N.; Pahwa, Savita G; Kalyanaraman, V. S.; Pergolizzi, R.; MacPhail, S.; Silver, J.

In: Clinical Immunology and Immunopathology, Vol. 76, No. 3 I, 01.01.1995, p. 255-265.

Research output: Contribution to journalArticle

Akolkar, PN, Gulwani-Akolkar, B, Chirmule, N, Pahwa, SG, Kalyanaraman, VS, Pergolizzi, R, MacPhail, S & Silver, J 1995, 'The HIV glycoprotein gp160 has superantigen-like properties', Clinical Immunology and Immunopathology, vol. 76, no. 3 I, pp. 255-265. https://doi.org/10.1006/clin.1995.1124
Akolkar PN, Gulwani-Akolkar B, Chirmule N, Pahwa SG, Kalyanaraman VS, Pergolizzi R et al. The HIV glycoprotein gp160 has superantigen-like properties. Clinical Immunology and Immunopathology. 1995 Jan 1;76(3 I):255-265. https://doi.org/10.1006/clin.1995.1124
Akolkar, P. N. ; Gulwani-Akolkar, B. ; Chirmule, N. ; Pahwa, Savita G ; Kalyanaraman, V. S. ; Pergolizzi, R. ; MacPhail, S. ; Silver, J. / The HIV glycoprotein gp160 has superantigen-like properties. In: Clinical Immunology and Immunopathology. 1995 ; Vol. 76, No. 3 I. pp. 255-265.
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