The HIV Glycoprotein gp160 Has Superantigen-like Properties

Pradip N. Akolkar, Beena Gulwani-Akolkar, Narendra Chirmule, Savita Pahwa, Vaniambadi S. Kalyanaraman, Robert Pergolizzi, Stuart Macphail, Jack Silver

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


HIV infection is characterized by paralysis of the immune system and a depletion of CD4+ cells. Recent studies demonstrating modulation of the Vβ T cell receptor (TCR) repertoire in HIV patients have suggested that some of these effects may be the result of action by one or more superantigens encoded by the virus. In order to determine whether the HIV envelope glycoprotein, gp160, displays properties reminiscent of a superantigen, the T cell receptor V,B repertoire of T cells from healthy, seronegative individuals activated in vitro with gp160 was determined. In five individuals of disparate HLA type, activation by gp160 resulted in a marked skewing in the relative expression of a common set of Vβ gene segments. This activation was HLA class II-dependent and did not require antigen processing. Surprisingly, the Vβ segments affected by gp160 bore a striking similarity to those affected by the staphylococcal superantigen SEB. These observations suggest that exposure to superantigens produced by opportunistic infection might play an important role in disease progression.

Original languageEnglish (US)
Pages (from-to)255-265
Number of pages11
JournalClinical Immunology and Immunopathology
Issue number3
StatePublished - Sep 1995
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology


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