The histologic basis of optic disk pallor in experimental optic atrophy

Harry A. Quigley, Douglas Anderson

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

We studied the clinical and microscopic appearances of the optic nerve head in squirrel monkeys with optic nerve degeneration produced by optic nerve transection at the orbital apex. The ophthalmoscopic development of optic disk pallor coincided with the loss of nerve fiber bundles and the rearrangement of the remaining disk astrocytes into dense parallel layers across the nerve head. No astrocytic mitoses were observed and the estimated volume of astrocytes increased only slightly from normal. Among the astrocytes in atrophic disks, many capillaries had patent lumens and ultrastructurally normal endothelial cells. Pallor of the optic disk seems to result from a decrease in the transmission of light into the cytoarchitecture of the atrophic nerve head, not from the absence of capillaries or from extensive astrocytic proliferation.

Original languageEnglish
Pages (from-to)709-717
Number of pages9
JournalAmerican Journal of Ophthalmology
Volume83
Issue number5
StatePublished - Jan 1 1977

Fingerprint

Pallor
Optic Atrophy
Optic Disk
Astrocytes
Optic Nerve Injuries
Saimiri
Nerve Degeneration
Optic Nerve
Nerve Fibers
Mitosis
Endothelial Cells
Light

ASJC Scopus subject areas

  • Ophthalmology

Cite this

The histologic basis of optic disk pallor in experimental optic atrophy. / Quigley, Harry A.; Anderson, Douglas.

In: American Journal of Ophthalmology, Vol. 83, No. 5, 01.01.1977, p. 709-717.

Research output: Contribution to journalArticle

Quigley, Harry A. ; Anderson, Douglas. / The histologic basis of optic disk pallor in experimental optic atrophy. In: American Journal of Ophthalmology. 1977 ; Vol. 83, No. 5. pp. 709-717.
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