Abstract
Clear cell adenocarcinoma of the lower urinary tract is a rare neoplasm whose histogenesis has not been thoroughly investigated. We have examined six specimens of clear cell adenocarcinomas collected from three institutions using histological, histochemical, and immunohistochemical techniques. Results indicate that almost all clear cell adenocarcinomas of this region express morphological and antigenic features, suggesting mullerian differentiation, and that mullerian differentiation is not a feature of either nonclear cell adenocarcinomas or normal female paraurethral glands. Including the authors' six specimens, 46 specimens have been reported in the available English literature. The accumulated experience confirms the initial impression that these tumors develop predominantly in the urethras of women and occur over a wide age range. Despite high stage at diagnosis, most patients have been alive with no evidence of disease when reported, a prognosis that seems to apply regardless of length of follow-up.
| Original language | English |
|---|---|
| Pages (from-to) | 248-252 |
| Number of pages | 5 |
| Journal | Human Pathology |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 20 1996 |
| Externally published | Yes |
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Keywords
- clear cell adenocarcinoma
- immunohistochemistry
- ultrastructure
- urethra
- urinary bladder
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
The histogenesis of clear cell adenocarcinoma of the lower urinary tract : Case series and review of the literature. / Drew, Peter A.; Murphy, William M.; Civantos, Francisco; Speights, V. O.
In: Human Pathology, Vol. 27, No. 3, 20.03.1996, p. 248-252.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The histogenesis of clear cell adenocarcinoma of the lower urinary tract
T2 - Case series and review of the literature
AU - Drew, Peter A.
AU - Murphy, William M.
AU - Civantos, Francisco
AU - Speights, V. O.
PY - 1996/3/20
Y1 - 1996/3/20
N2 - Clear cell adenocarcinoma of the lower urinary tract is a rare neoplasm whose histogenesis has not been thoroughly investigated. We have examined six specimens of clear cell adenocarcinomas collected from three institutions using histological, histochemical, and immunohistochemical techniques. Results indicate that almost all clear cell adenocarcinomas of this region express morphological and antigenic features, suggesting mullerian differentiation, and that mullerian differentiation is not a feature of either nonclear cell adenocarcinomas or normal female paraurethral glands. Including the authors' six specimens, 46 specimens have been reported in the available English literature. The accumulated experience confirms the initial impression that these tumors develop predominantly in the urethras of women and occur over a wide age range. Despite high stage at diagnosis, most patients have been alive with no evidence of disease when reported, a prognosis that seems to apply regardless of length of follow-up.
AB - Clear cell adenocarcinoma of the lower urinary tract is a rare neoplasm whose histogenesis has not been thoroughly investigated. We have examined six specimens of clear cell adenocarcinomas collected from three institutions using histological, histochemical, and immunohistochemical techniques. Results indicate that almost all clear cell adenocarcinomas of this region express morphological and antigenic features, suggesting mullerian differentiation, and that mullerian differentiation is not a feature of either nonclear cell adenocarcinomas or normal female paraurethral glands. Including the authors' six specimens, 46 specimens have been reported in the available English literature. The accumulated experience confirms the initial impression that these tumors develop predominantly in the urethras of women and occur over a wide age range. Despite high stage at diagnosis, most patients have been alive with no evidence of disease when reported, a prognosis that seems to apply regardless of length of follow-up.
KW - clear cell adenocarcinoma
KW - immunohistochemistry
KW - ultrastructure
KW - urethra
KW - urinary bladder
UR - http://www.scopus.com/inward/record.url?scp=0029921172&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029921172&partnerID=8YFLogxK
U2 - 10.1016/S0046-8177(96)90064-7
DO - 10.1016/S0046-8177(96)90064-7
M3 - Article
VL - 27
SP - 248
EP - 252
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 3
ER -