The histogenesis of clear cell adenocarcinoma of the lower urinary tract

Case series and review of the literature

Peter A. Drew, William M. Murphy, Francisco Civantos, V. O. Speights

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Clear cell adenocarcinoma of the lower urinary tract is a rare neoplasm whose histogenesis has not been thoroughly investigated. We have examined six specimens of clear cell adenocarcinomas collected from three institutions using histological, histochemical, and immunohistochemical techniques. Results indicate that almost all clear cell adenocarcinomas of this region express morphological and antigenic features, suggesting mullerian differentiation, and that mullerian differentiation is not a feature of either nonclear cell adenocarcinomas or normal female paraurethral glands. Including the authors' six specimens, 46 specimens have been reported in the available English literature. The accumulated experience confirms the initial impression that these tumors develop predominantly in the urethras of women and occur over a wide age range. Despite high stage at diagnosis, most patients have been alive with no evidence of disease when reported, a prognosis that seems to apply regardless of length of follow-up.

Original languageEnglish
Pages (from-to)248-252
Number of pages5
JournalHuman Pathology
Volume27
Issue number3
DOIs
StatePublished - Mar 20 1996
Externally publishedYes

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Clear Cell Adenocarcinoma
Urinary Tract
Naphazoline
Literature
Urethra
Neoplasms
Adenocarcinoma

Keywords

  • clear cell adenocarcinoma
  • immunohistochemistry
  • ultrastructure
  • urethra
  • urinary bladder

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

The histogenesis of clear cell adenocarcinoma of the lower urinary tract : Case series and review of the literature. / Drew, Peter A.; Murphy, William M.; Civantos, Francisco; Speights, V. O.

In: Human Pathology, Vol. 27, No. 3, 20.03.1996, p. 248-252.

Research output: Contribution to journalArticle

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