The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication

Levi J. Yant, Thomas C. Friedrich, Randall C. Johnson, Gemma E. May, Nicholas J. Maness, Alissa M. Enz, Jeffrey D. Lifson, David H. O'Connor, Mary Carrington, David I. Watkins

Research output: Contribution to journalArticle

220 Scopus citations

Abstract

Particular HLA alleles are associated with reduced human immunodeficiency virus replication. It has been difficult, however, to characterize the immune correlates of viral control. An analysis of the influence of major histocompatibility complex class I alleles on viral control in 181 simian immunodeficiency virus SIVmac239-infected rhesus macaques revealed that Mamu-B*17 was associated with a 26-fold reduction in plasma virus concentrations (P < 0.001). Mamu-B*17 was also enriched 1,000-fold in a group of animals that controlled viral replication. Even after accounting for this group, Mamu-B*17 was associated with an eightfold reduction in plasma virus concentrations (P < 0.001). Mamu-B*17-positive macaques could, therefore, facilitate our understanding of the correlates of viral control.

Original languageEnglish (US)
Pages (from-to)5074-5077
Number of pages4
JournalJournal of virology
Volume80
Issue number10
DOIs
StatePublished - May 2006

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Yant, L. J., Friedrich, T. C., Johnson, R. C., May, G. E., Maness, N. J., Enz, A. M., Lifson, J. D., O'Connor, D. H., Carrington, M., & Watkins, D. I. (2006). The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication. Journal of virology, 80(10), 5074-5077. https://doi.org/10.1128/JVI.80.10.5074-5077.2006