The Hair Follicle as a Dynamic Miniorgan

Marlon R. Schneider, Ruth Schmidt-Ullrich, Ralf Paus

Research output: Contribution to journalReview article

401 Citations (Scopus)

Abstract

Hair is a primary characteristic of mammals, and exerts a wide range of functions including thermoregulation, physical protection, sensory activity, and social interactions. The hair shaft consists of terminally differentiated keratinocytes that are produced by the hair follicle. Hair follicle development takes place during fetal skin development and relies on tightly regulated ectodermal-mesodermal interactions. After birth, mature and actively growing hair follicles eventually become anchored in the subcutis, and periodically regenerate by spontaneously undergoing repetitive cycles of growth (anagen), apoptosis-driven regression (catagen), and relative quiescence (telogen). Our molecular understanding of hair follicle biology relies heavily on mouse mutants with abnormalities in hair structure, growth, and/or pigmentation. These mice have allowed novel insights into important general molecular and cellular processes beyond skin and hair biology, ranging from organ induction, morphogenesis and regeneration, to pigment and stem cell biology, cell proliferation, migration and apoptosis. In this review, we present basic concepts of hair follicle biology and summarize important recent advances in the field.

Original languageEnglish (US)
JournalCurrent Biology
Volume19
Issue number3
DOIs
StatePublished - Feb 10 2009
Externally publishedYes

Fingerprint

hair follicles
Hair Follicle
Hair
trichomes
Skin
skin (animal)
Biological Sciences
Cytology
Apoptosis
Mammals
apoptosis
Cell proliferation
Stem cells
Pigments
Body Temperature Regulation
keratinocytes
mice
Pigmentation
thermoregulation
Interpersonal Relations

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

The Hair Follicle as a Dynamic Miniorgan. / Schneider, Marlon R.; Schmidt-Ullrich, Ruth; Paus, Ralf.

In: Current Biology, Vol. 19, No. 3, 10.02.2009.

Research output: Contribution to journalReview article

Schneider, Marlon R. ; Schmidt-Ullrich, Ruth ; Paus, Ralf. / The Hair Follicle as a Dynamic Miniorgan. In: Current Biology. 2009 ; Vol. 19, No. 3.
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