The H1c haplotype at the MAPT locus is associated with Alzheimer's disease

Amanda J Myers, M. Kaleem, L. Marlowe, A. M. Pittman, A. J. Lees, H. C. Fung, J. Duckworth, D. Leung, A. Gibson, C. M. Morris, R. de Silva, J. Hardy

Research output: Contribution to journalArticle

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Abstract

Although it is clear that microtubule associated protein tau (MAPT) is involved in Alzheimer's disease (AD) pathology, it has not been clear whether it is involved genetically. We have recently examined the MAPT locus in progressive supranuclear palsy and found that a haplotype (H1c) on the background of the well-described H1 clade is associated with PSP. Here we report that the same haplotype is associated with the risk of AD in two autopsy confirmed series of cases with ages at death >65 years.

Original languageEnglish
Pages (from-to)2399-2404
Number of pages6
JournalHuman Molecular Genetics
Volume14
Issue number16
DOIs
StatePublished - Aug 15 2005
Externally publishedYes

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Microtubule-Associated Proteins
Haplotypes
Alzheimer Disease
Progressive Supranuclear Palsy
Autopsy
Pathology
Primary Spontaneous Pneumothorax

ASJC Scopus subject areas

  • Genetics

Cite this

Myers, A. J., Kaleem, M., Marlowe, L., Pittman, A. M., Lees, A. J., Fung, H. C., ... Hardy, J. (2005). The H1c haplotype at the MAPT locus is associated with Alzheimer's disease. Human Molecular Genetics, 14(16), 2399-2404. https://doi.org/10.1093/hmg/ddi241

The H1c haplotype at the MAPT locus is associated with Alzheimer's disease. / Myers, Amanda J; Kaleem, M.; Marlowe, L.; Pittman, A. M.; Lees, A. J.; Fung, H. C.; Duckworth, J.; Leung, D.; Gibson, A.; Morris, C. M.; de Silva, R.; Hardy, J.

In: Human Molecular Genetics, Vol. 14, No. 16, 15.08.2005, p. 2399-2404.

Research output: Contribution to journalArticle

Myers, AJ, Kaleem, M, Marlowe, L, Pittman, AM, Lees, AJ, Fung, HC, Duckworth, J, Leung, D, Gibson, A, Morris, CM, de Silva, R & Hardy, J 2005, 'The H1c haplotype at the MAPT locus is associated with Alzheimer's disease', Human Molecular Genetics, vol. 14, no. 16, pp. 2399-2404. https://doi.org/10.1093/hmg/ddi241
Myers, Amanda J ; Kaleem, M. ; Marlowe, L. ; Pittman, A. M. ; Lees, A. J. ; Fung, H. C. ; Duckworth, J. ; Leung, D. ; Gibson, A. ; Morris, C. M. ; de Silva, R. ; Hardy, J. / The H1c haplotype at the MAPT locus is associated with Alzheimer's disease. In: Human Molecular Genetics. 2005 ; Vol. 14, No. 16. pp. 2399-2404.
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