The H1c haplotype at the MAPT locus is associated with Alzheimer's disease

A. J. Myers, M. Kaleem, L. Marlowe, A. M. Pittman, A. J. Lees, H. C. Fung, J. Duckworth, D. Leung, A. Gibson, C. M. Morris, R. de Silva, J. Hardy

Research output: Contribution to journalArticle

160 Scopus citations

Abstract

Although it is clear that microtubule associated protein tau (MAPT) is involved in Alzheimer's disease (AD) pathology, it has not been clear whether it is involved genetically. We have recently examined the MAPT locus in progressive supranuclear palsy and found that a haplotype (H1c) on the background of the well-described H1 clade is associated with PSP. Here we report that the same haplotype is associated with the risk of AD in two autopsy confirmed series of cases with ages at death >65 years.

Original languageEnglish (US)
Pages (from-to)2399-2404
Number of pages6
JournalHuman molecular genetics
Volume14
Issue number16
DOIs
StatePublished - Aug 15 2005

    Fingerprint

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Myers, A. J., Kaleem, M., Marlowe, L., Pittman, A. M., Lees, A. J., Fung, H. C., Duckworth, J., Leung, D., Gibson, A., Morris, C. M., de Silva, R., & Hardy, J. (2005). The H1c haplotype at the MAPT locus is associated with Alzheimer's disease. Human molecular genetics, 14(16), 2399-2404. https://doi.org/10.1093/hmg/ddi241