The growth factor receptor ERBB2 regulates mitochondrial activity on a signaling time scale

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Overexpressed UCP2 and ERBB2 are oncogenic, but their functions at low expression are unclear. Results: ERBB2 regulates UCP2 levels at low and overexpression settings. The rapid regulation of mitochondria by ERBB2 requires UCP2, but not its transporter activity. Conclusion: At low levels, UCP2 integrates mitochondria into the acute (2 h) signaling response. Significance: This study links growth factor signaling, mitochondrial adaptability, and oncogenic deregulation.

Original languageEnglish
Pages (from-to)35253-35265
Number of pages13
JournalJournal of Biological Chemistry
Volume288
Issue number49
DOIs
StatePublished - Dec 6 2013

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Mitochondria
Growth Factor Receptors
Deregulation
Intercellular Signaling Peptides and Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

The growth factor receptor ERBB2 regulates mitochondrial activity on a signaling time scale. / Patel, Nirav; Barrientos, Antonio; Landgraf, Ralf.

In: Journal of Biological Chemistry, Vol. 288, No. 49, 06.12.2013, p. 35253-35265.

Research output: Contribution to journalArticle

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