The growth factor receptor ERBB2 regulates mitochondrial activity on a signaling time scale

Nirav Patel; Antoni Barrientos; Ralf Landgraf

doi:10.1074/jbc.M113.478271

The growth factor receptor ERBB2 regulates mitochondrial activity on a signaling time scale

Nirav Patel, Antoni Barrientos, Ralf Landgraf

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: Overexpressed UCP2 and ERBB2 are oncogenic, but their functions at low expression are unclear. Results: ERBB2 regulates UCP2 levels at low and overexpression settings. The rapid regulation of mitochondria by ERBB2 requires UCP2, but not its transporter activity. Conclusion: At low levels, UCP2 integrates mitochondria into the acute (2 h) signaling response. Significance: This study links growth factor signaling, mitochondrial adaptability, and oncogenic deregulation.

Original language	English (US)
Pages (from-to)	35253-35265
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	49
DOIs	https://doi.org/10.1074/jbc.M113.478271
State	Published - Dec 6 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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abstract = "Background: Overexpressed UCP2 and ERBB2 are oncogenic, but their functions at low expression are unclear. Results: ERBB2 regulates UCP2 levels at low and overexpression settings. The rapid regulation of mitochondria by ERBB2 requires UCP2, but not its transporter activity. Conclusion: At low levels, UCP2 integrates mitochondria into the acute (2 h) signaling response. Significance: This study links growth factor signaling, mitochondrial adaptability, and oncogenic deregulation.",

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AB - Background: Overexpressed UCP2 and ERBB2 are oncogenic, but their functions at low expression are unclear. Results: ERBB2 regulates UCP2 levels at low and overexpression settings. The rapid regulation of mitochondria by ERBB2 requires UCP2, but not its transporter activity. Conclusion: At low levels, UCP2 integrates mitochondria into the acute (2 h) signaling response. Significance: This study links growth factor signaling, mitochondrial adaptability, and oncogenic deregulation.

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