Abstract
Background: Overexpressed UCP2 and ERBB2 are oncogenic, but their functions at low expression are unclear. Results: ERBB2 regulates UCP2 levels at low and overexpression settings. The rapid regulation of mitochondria by ERBB2 requires UCP2, but not its transporter activity. Conclusion: At low levels, UCP2 integrates mitochondria into the acute (2 h) signaling response. Significance: This study links growth factor signaling, mitochondrial adaptability, and oncogenic deregulation.
| Original language | English |
|---|---|
| Pages (from-to) | 35253-35265 |
| Number of pages | 13 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 49 |
| DOIs | |
| State | Published - Dec 6 2013 |
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ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
Cite this
The growth factor receptor ERBB2 regulates mitochondrial activity on a signaling time scale. / Patel, Nirav; Barrientos, Antonio; Landgraf, Ralf.
In: Journal of Biological Chemistry, Vol. 288, No. 49, 06.12.2013, p. 35253-35265.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The growth factor receptor ERBB2 regulates mitochondrial activity on a signaling time scale
AU - Patel, Nirav
AU - Barrientos, Antonio
AU - Landgraf, Ralf
PY - 2013/12/6
Y1 - 2013/12/6
N2 - Background: Overexpressed UCP2 and ERBB2 are oncogenic, but their functions at low expression are unclear. Results: ERBB2 regulates UCP2 levels at low and overexpression settings. The rapid regulation of mitochondria by ERBB2 requires UCP2, but not its transporter activity. Conclusion: At low levels, UCP2 integrates mitochondria into the acute (2 h) signaling response. Significance: This study links growth factor signaling, mitochondrial adaptability, and oncogenic deregulation.
AB - Background: Overexpressed UCP2 and ERBB2 are oncogenic, but their functions at low expression are unclear. Results: ERBB2 regulates UCP2 levels at low and overexpression settings. The rapid regulation of mitochondria by ERBB2 requires UCP2, but not its transporter activity. Conclusion: At low levels, UCP2 integrates mitochondria into the acute (2 h) signaling response. Significance: This study links growth factor signaling, mitochondrial adaptability, and oncogenic deregulation.
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UR - http://www.scopus.com/inward/citedby.url?scp=84890303109&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.478271
DO - 10.1074/jbc.M113.478271
M3 - Article
VL - 288
SP - 35253
EP - 35265
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 49
ER -