The growth factor receptor ERBB2 regulates mitochondrial activity on a signaling time scale

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Background: Overexpressed UCP2 and ERBB2 are oncogenic, but their functions at low expression are unclear. Results: ERBB2 regulates UCP2 levels at low and overexpression settings. The rapid regulation of mitochondria by ERBB2 requires UCP2, but not its transporter activity. Conclusion: At low levels, UCP2 integrates mitochondria into the acute (2 h) signaling response. Significance: This study links growth factor signaling, mitochondrial adaptability, and oncogenic deregulation.

Original languageEnglish (US)
Pages (from-to)35253-35265
Number of pages13
JournalJournal of Biological Chemistry
Issue number49
StatePublished - Dec 6 2013


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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