TY - JOUR
T1 - The growth factor receptor ERBB2 regulates mitochondrial activity on a signaling time scale
AU - Patel, Nirav
AU - Barrientos, Antoni
AU - Landgraf, Ralf
PY - 2013/12/6
Y1 - 2013/12/6
N2 - Background: Overexpressed UCP2 and ERBB2 are oncogenic, but their functions at low expression are unclear. Results: ERBB2 regulates UCP2 levels at low and overexpression settings. The rapid regulation of mitochondria by ERBB2 requires UCP2, but not its transporter activity. Conclusion: At low levels, UCP2 integrates mitochondria into the acute (2 h) signaling response. Significance: This study links growth factor signaling, mitochondrial adaptability, and oncogenic deregulation.
AB - Background: Overexpressed UCP2 and ERBB2 are oncogenic, but their functions at low expression are unclear. Results: ERBB2 regulates UCP2 levels at low and overexpression settings. The rapid regulation of mitochondria by ERBB2 requires UCP2, but not its transporter activity. Conclusion: At low levels, UCP2 integrates mitochondria into the acute (2 h) signaling response. Significance: This study links growth factor signaling, mitochondrial adaptability, and oncogenic deregulation.
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U2 - 10.1074/jbc.M113.478271
DO - 10.1074/jbc.M113.478271
M3 - Article
C2 - 24142693
AN - SCOPUS:84890303109
VL - 288
SP - 35253
EP - 35265
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 49
ER -