The glamour and gloom of glycogen synthase kinase-3

Richard S. Jope, Gail V.W. Johnson

Research output: Contribution to journalReview articlepeer-review

1237 Scopus citations

Abstract

Glycogen synthase kinase-3 (GSK3) is now recognized as a key component of a surprisingly large number of cellular processes and diseases. Several mechanisms play a part in controlling the actions of GSK3, including phosphorylation, protein complex formation, and subcellular distribution. These are used to control and direct the far-reaching influences of GSK3 on cellular structure, growth, motility and apoptosis. Dysregulation of GSK3 is linked to several prevalent pathological conditions, such as diabetes and/or insulin resistance, and Alzheimer's disease. Therefore, much effort is currently directed towards understanding the functions and control of GSK3, and identifying methods capable of diminishing the deleterious impact of GSK3 in pathological conditions.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalTrends in Biochemical Sciences
Volume29
Issue number2
DOIs
StatePublished - Feb 2004
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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