TY - JOUR
T1 - The genome of the crustacean parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion
AU - Kao, Damian
AU - Lai, Alvina G.
AU - Stamataki, Evangelia
AU - Rosic, Silvana
AU - Konstantinides, Nikolaos
AU - Jarvis, Erin
AU - Di Donfrancesco, Alessia
AU - Pouchkina-Stancheva, Natalia
AU - Semon, Marie
AU - Grillo, Marco
AU - Bruce, Heather
AU - Kumar, Suyash
AU - Siwanowicz, Igor
AU - Le, Andy
AU - Lemire, Andrew
AU - Eisen, Michael B.
AU - Extavour, Cassandra
AU - Browne, William E.
AU - Wolff, Carsten
AU - Averof, Michalis
AU - Patel, Nipam H.
AU - Sarkies, Peter
AU - Pavlopoulos, Anastasios
AU - Aboobaker, Aziz
N1 - Funding Information:
Biotechnology and Biological Sciences Research Council BB/K007564/1, Medical Research Council MR/M000133/1, Human Frontier Science Program, University of Oxford Elizabeth Hannah Jenkinson Fund, Howard Hughes Medical Institute, Medical Research Council MRC MC-A652-5PZ80, Agence Nationale de la Recherche ANR-12-CHEX-0001-01, National Science Foundation IOS-1257379, Imperial College London, John Fell Fund, University of Oxford. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
PY - 2016/11/16
Y1 - 2016/11/16
N2 - The amphipod crustacean Parhyale hawaiensis is a blossoming model system for studies of developmental mechanisms and more recently regeneration. We have sequenced the genome allowing annotation of all key signaling pathways, transcription factors, and non-coding RNAs that will enhance ongoing functional studies. Parhyale is a member of the Malacostraca clade, which includes crustacean food crop species. We analysed the immunity related genes of Parhyale as an important comparative system for these species, where immunity related aquaculture problems have increased as farming has intensified. We also find that Parhyale and other species within Multicrustacea contain the enzyme sets necessary to perform lignocellulose digestion (’wood eating’), suggesting this ability may predate the diversification of this lineage. Our data provide an essential resource for further development of Parhyale as an experimental model. The first malacostracan genome will underpin ongoing comparative work in food crop species and research investigating lignocellulose as an energy source.
AB - The amphipod crustacean Parhyale hawaiensis is a blossoming model system for studies of developmental mechanisms and more recently regeneration. We have sequenced the genome allowing annotation of all key signaling pathways, transcription factors, and non-coding RNAs that will enhance ongoing functional studies. Parhyale is a member of the Malacostraca clade, which includes crustacean food crop species. We analysed the immunity related genes of Parhyale as an important comparative system for these species, where immunity related aquaculture problems have increased as farming has intensified. We also find that Parhyale and other species within Multicrustacea contain the enzyme sets necessary to perform lignocellulose digestion (’wood eating’), suggesting this ability may predate the diversification of this lineage. Our data provide an essential resource for further development of Parhyale as an experimental model. The first malacostracan genome will underpin ongoing comparative work in food crop species and research investigating lignocellulose as an energy source.
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U2 - 10.7554/eLife.20062.001
DO - 10.7554/eLife.20062.001
M3 - Article
C2 - 27849518
AN - SCOPUS:84997764963
VL - 5
JO - eLife
JF - eLife
SN - 2050-084X
IS - November 2016
M1 - e20062
ER -