The genetics of late-onset Alzheimer's disease

Amanda J. Myers, Alison M. Goate

Research output: Contribution to journalReview article

66 Scopus citations

Abstract

Of late-onset Alzheimer's disease patients 50% do not carry an apolipoprotein E ε4 allele, indicating that there must be other genetic or environmental risk factors for the disease. During the past few years, both genetic linkage and candidate gene studies have been undertaken in order to identify novel genetic risk factors for late-onset Alzheimer's disease. Previous genome screens implicated a region of chromosome 12 that contains the genes that encode both α2-macroglobulin and the low-density lipoprotein receptor-related protein. However, candidate gene studies have produced mixed results with respect to both of these genes. New linkage studies now provide strong evidence for Alzheimer's disease susceptibility loci on chromosomes 9 and 10. The locus on chromosome 10 very probably modifies risk for Aizheimer's disease by modulating β-amyloid-42 levels.

Original languageEnglish (US)
Pages (from-to)433-440
Number of pages8
JournalCurrent Opinion in Neurology
Volume14
Issue number4
DOIs
StatePublished - Aug 14 2001

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ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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