The genetics of hereditary spastic paraplegia and implications for drug therapy

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Hereditary spastic paraplegia (HSP) comprises a group of clinically and genetically heterogeneous diseases that affect the upper motor neurons and their axonal projections. A total of 30 chromosomal loci have been identified for autosomal dominant, recessive and X-linked HSP. The underlying genes for 15 of these loci have been described. The molecular dissection of the cellular functions of the related gene products has already greatly advanced our understanding of the most critical pathways involved in HSP. It is hoped that in the foreseeable future this knowledge will begin to translate into novel pharmacological approaches for this devastating disease.

Original languageEnglish
Pages (from-to)1433-1439
Number of pages7
JournalExpert Opinion on Pharmacotherapy
Volume8
Issue number10
DOIs
StatePublished - Jul 1 2007

Fingerprint

Hereditary Spastic Paraplegia
Drug Therapy
Motor Neuron Disease
Critical Pathways
Genes
Dissection
Pharmacology

Keywords

  • Genetics
  • Spastic paraplegia

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

The genetics of hereditary spastic paraplegia and implications for drug therapy. / Zuchner, Stephan L.

In: Expert Opinion on Pharmacotherapy, Vol. 8, No. 10, 01.07.2007, p. 1433-1439.

Research output: Contribution to journalArticle

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