The genetics of hereditary spastic paraplegia and implications for drug therapy

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20 Scopus citations


Hereditary spastic paraplegia (HSP) comprises a group of clinically and genetically heterogeneous diseases that affect the upper motor neurons and their axonal projections. A total of 30 chromosomal loci have been identified for autosomal dominant, recessive and X-linked HSP. The underlying genes for 15 of these loci have been described. The molecular dissection of the cellular functions of the related gene products has already greatly advanced our understanding of the most critical pathways involved in HSP. It is hoped that in the foreseeable future this knowledge will begin to translate into novel pharmacological approaches for this devastating disease.

Original languageEnglish (US)
Pages (from-to)1433-1439
Number of pages7
JournalExpert Opinion on Pharmacotherapy
Issue number10
StatePublished - Jul 2007


  • Genetics
  • Spastic paraplegia

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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