The gastrin gene promoter is regulated by p73 isoforms in tumor cells

K. Tomkova, W. El-Rifai, A. Vilgelm, M. C. Kelly, T. C. Wang, A. I. Zaika

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

p73, a new p53 family member, is a transcription factor that is increasingly recognized in cancer research as an important player in tumorigenesis as well as in chemotherapeutic drug sensitivity. Despite the substantial structural and functional similarities to p53, accumulating evidence suggests that p53 and p73 may differently regulate their transcriptional targets. In this study, we have investigated the role of p73 in regulation of the gastrin gene promoter. Gastrin is a peptide hormone and an important factor in determining the progression of a number of human malignancies. Our results show that p73 can bind to the gastrin promoter. This leads to transcriptional upregulation of gastrin mRNA. We also found that the levels of gastrin and p73 transcripts correlate in primary gastric tumors. Taken together, our results demonstrate a novel mechanism for regulation of gastrin gene transcription and support a concept that p53 and p73 may have different biological roles in tumors.

Original languageEnglish (US)
Pages (from-to)6032-6036
Number of pages5
JournalOncogene
Volume25
Issue number44
DOIs
StatePublished - Sep 28 2006
Externally publishedYes

Keywords

  • Colorectal tumor
  • Esophageal tumor
  • Gastric tumor
  • p53
  • p63
  • p73

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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