The functional role of interhemispheric interactions in human motor control

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Interhemispheric interactions in the motor system have been extensively examined using transcranial magnetic stimulation (TMS). Paired-pulse TMS and the ipsilateral silent period (iSP) are the most widely used techniques to quantify interhemispheric inhibitory interactions between primary motor cortices in humans. This review will discuss the use of these techniques during unimanual and bimanual actions. The available evidence provides a framework for understanding the contribution of inhibitory interactions to the control of a resting limb during unilateral actions, while their role in the control of a limb executing a motor action remains poorly understood. Evidence shows that during bilateral actions voluntary activity of one hand can influence interhemispheric inhibitory interactions controlling the contralateral active hand. All studies point to the view that the modulation of interhemispheric interactions in the motor system changes in a task-dependent manner. These results might be of interest for patients with motor disorders and emphasizes the need of a careful interpretation when extrapolating results between different motor actions.

Original languageEnglish (US)
Title of host publicationCortical Connectivity
Subtitle of host publicationBrain Stimulation for Assessing and Modulating Cortical Connectivity and Function
PublisherSpringer-Verlag Berlin Heidelberg
Number of pages17
ISBN (Electronic)9783642327674
ISBN (Print)3642327664, 9783642327667
StatePublished - Jul 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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