The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation

Jose Renato Pinto, Aldrin V. Gomes, Michelle A. Jones, Jingsheng Liang, Susan Nguyen, Todd Miller, Michelle S. Parvatiyar, James D. Potter

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The role of HSSTnT in cardiac muscle regulation is unknown. Results: HSSTnT isoforms regulate Ca2+ sensitivity and maximal force of contraction in skinned fibers in a different fashion compared with HCTnT3. Conclusion: HSSTnT isoforms despite being homologues of CTnT display distinct functional properties. Significance: The HSSTnT isoforms, when expressed in the heart, would play a specific role in desensitizing the myofilament toCa2+.

Original languageEnglish
Pages (from-to)37362-37370
Number of pages9
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012
Externally publishedYes

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Troponin T
Muscle
Myocardium
Protein Isoforms
Myofibrils
Fibers

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Pinto, J. R., Gomes, A. V., Jones, M. A., Liang, J., Nguyen, S., Miller, T., ... Potter, J. D. (2012). The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation. Journal of Biological Chemistry, 287(44), 37362-37370. https://doi.org/10.1074/jbc.M112.364927

The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation. / Pinto, Jose Renato; Gomes, Aldrin V.; Jones, Michelle A.; Liang, Jingsheng; Nguyen, Susan; Miller, Todd; Parvatiyar, Michelle S.; Potter, James D.

In: Journal of Biological Chemistry, Vol. 287, No. 44, 26.10.2012, p. 37362-37370.

Research output: Contribution to journalArticle

Pinto, JR, Gomes, AV, Jones, MA, Liang, J, Nguyen, S, Miller, T, Parvatiyar, MS & Potter, JD 2012, 'The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation', Journal of Biological Chemistry, vol. 287, no. 44, pp. 37362-37370. https://doi.org/10.1074/jbc.M112.364927
Pinto, Jose Renato ; Gomes, Aldrin V. ; Jones, Michelle A. ; Liang, Jingsheng ; Nguyen, Susan ; Miller, Todd ; Parvatiyar, Michelle S. ; Potter, James D. / The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation. In: Journal of Biological Chemistry. 2012 ; Vol. 287, No. 44. pp. 37362-37370.
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