Abstract
OBJECTIVE: Measure the fraction of inspired oxygen (F IO2) in infants receiving supplemental oxygen via nasal cannula and identify clinical variables that affect F IO2. METHODS: Hypopharyngeal gas samples were obtained from 20 infants receiving oxygen via nasal cannula at flows between 0 and 4 L/min. F IO2 was calculated using the alveolar gas equation and measurements of partial pressure of oxygen in the samples and the barometric pressure. RESULTS: F IO2 increased as oxygen flow was increased. F IO2 exceeded safe levels (> 60%) in two thirds of samples when the oxygen flow was 2 L/min or higher. Tachypnea (respiratory rate > 40 breaths/min) was associated with lower F IO2. CONCLUSION: Infants receiving oxygen via nasal cannula at ≥ 2 L/min may be at risk for hyperoxic lung injury. Therefore, we recommend using the lowest possible oxygen flow needed to maintain normoxia in infants requiring prolonged oxygen therapy via nasal cannula.
| Original language | English |
|---|---|
| Pages (from-to) | 897-901 |
| Number of pages | 5 |
| Journal | Respiratory Care |
| Volume | 46 |
| Issue number | 9 |
| State | Published - Sep 1 2001 |
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Keywords
- Free radicals
- Hyperoxia
- Lung injury
- Oxygen toxicity
- Pediatrics
- Respiratory failure
- Respiratory therapy
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
The fraction of inspired oxygen in infants receiving oxygen via nasal cannula often exceeds safe levels. / Kuluz, John W.; McLaughlin, Gwenn E; Gelman, Barry; Patricia Cantwell, G.; Thomas, James; Mahon, Thomas; Schleien, Charles L.
In: Respiratory Care, Vol. 46, No. 9, 01.09.2001, p. 897-901.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The fraction of inspired oxygen in infants receiving oxygen via nasal cannula often exceeds safe levels
AU - Kuluz, John W.
AU - McLaughlin, Gwenn E
AU - Gelman, Barry
AU - Patricia Cantwell, G.
AU - Thomas, James
AU - Mahon, Thomas
AU - Schleien, Charles L.
PY - 2001/9/1
Y1 - 2001/9/1
N2 - OBJECTIVE: Measure the fraction of inspired oxygen (F IO2) in infants receiving supplemental oxygen via nasal cannula and identify clinical variables that affect F IO2. METHODS: Hypopharyngeal gas samples were obtained from 20 infants receiving oxygen via nasal cannula at flows between 0 and 4 L/min. F IO2 was calculated using the alveolar gas equation and measurements of partial pressure of oxygen in the samples and the barometric pressure. RESULTS: F IO2 increased as oxygen flow was increased. F IO2 exceeded safe levels (> 60%) in two thirds of samples when the oxygen flow was 2 L/min or higher. Tachypnea (respiratory rate > 40 breaths/min) was associated with lower F IO2. CONCLUSION: Infants receiving oxygen via nasal cannula at ≥ 2 L/min may be at risk for hyperoxic lung injury. Therefore, we recommend using the lowest possible oxygen flow needed to maintain normoxia in infants requiring prolonged oxygen therapy via nasal cannula.
AB - OBJECTIVE: Measure the fraction of inspired oxygen (F IO2) in infants receiving supplemental oxygen via nasal cannula and identify clinical variables that affect F IO2. METHODS: Hypopharyngeal gas samples were obtained from 20 infants receiving oxygen via nasal cannula at flows between 0 and 4 L/min. F IO2 was calculated using the alveolar gas equation and measurements of partial pressure of oxygen in the samples and the barometric pressure. RESULTS: F IO2 increased as oxygen flow was increased. F IO2 exceeded safe levels (> 60%) in two thirds of samples when the oxygen flow was 2 L/min or higher. Tachypnea (respiratory rate > 40 breaths/min) was associated with lower F IO2. CONCLUSION: Infants receiving oxygen via nasal cannula at ≥ 2 L/min may be at risk for hyperoxic lung injury. Therefore, we recommend using the lowest possible oxygen flow needed to maintain normoxia in infants requiring prolonged oxygen therapy via nasal cannula.
KW - Free radicals
KW - Hyperoxia
KW - Lung injury
KW - Oxygen toxicity
KW - Pediatrics
KW - Respiratory failure
KW - Respiratory therapy
UR - http://www.scopus.com/inward/record.url?scp=0035461245&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035461245&partnerID=8YFLogxK
M3 - Article
C2 - 11513761
AN - SCOPUS:0035461245
VL - 46
SP - 897
EP - 901
JO - Respiratory Care
JF - Respiratory Care
SN - 0098-9142
IS - 9
ER -