The fraction of inspired oxygen in infants receiving oxygen via nasal cannula often exceeds safe levels

John W. Kuluz, Gwenn E. McLaughlin, Barry Gelman, G. Patricia Cantwell, James Thomas, Thomas Mahon, Charles L. Schleien

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

OBJECTIVE: Measure the fraction of inspired oxygen (F IO2) in infants receiving supplemental oxygen via nasal cannula and identify clinical variables that affect F IO2. METHODS: Hypopharyngeal gas samples were obtained from 20 infants receiving oxygen via nasal cannula at flows between 0 and 4 L/min. F IO2 was calculated using the alveolar gas equation and measurements of partial pressure of oxygen in the samples and the barometric pressure. RESULTS: F IO2 increased as oxygen flow was increased. F IO2 exceeded safe levels (> 60%) in two thirds of samples when the oxygen flow was 2 L/min or higher. Tachypnea (respiratory rate > 40 breaths/min) was associated with lower F IO2. CONCLUSION: Infants receiving oxygen via nasal cannula at ≥ 2 L/min may be at risk for hyperoxic lung injury. Therefore, we recommend using the lowest possible oxygen flow needed to maintain normoxia in infants requiring prolonged oxygen therapy via nasal cannula.

Original languageEnglish (US)
Pages (from-to)897-901
Number of pages5
JournalRespiratory care
Volume46
Issue number9
StatePublished - Sep 1 2001

Keywords

  • Free radicals
  • Hyperoxia
  • Lung injury
  • Oxygen toxicity
  • Pediatrics
  • Respiratory failure
  • Respiratory therapy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Kuluz, J. W., McLaughlin, G. E., Gelman, B., Cantwell, G. P., Thomas, J., Mahon, T., & Schleien, C. L. (2001). The fraction of inspired oxygen in infants receiving oxygen via nasal cannula often exceeds safe levels. Respiratory care, 46(9), 897-901.