The female 'insulin advantage' in a biracial cohort

Results from the Miami Community Health Study

R. P. Donahue, R. J. Prineas, R. DeCarlo Donahue, J. A. Bean, Jay S Skyler

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

OBJECTIVE: To determine the extent to which gender differences in the rate of insulin-mediated glucose disposal are influenced by differences in body fatness. DESIGN: A cross-sectional study of a biracial sample of men and women drawn from a population-based study. SUBJECTS: Twenty-five 25-44 year old residents of Dade County, FL. Twenty-five African-Americans (14 men and 11 women) and 28 white, nonHispanics (15 men and 13 women). All participants were free of diabetes mellitus (WHO Criteria). MEASUREMENTS: All persons volunteered to undergo a hyperinsulinemic euglycemic clamp procedure to determine the rate of insulin-mediated glucose disposal (insulin sensitivity, M). Several measures of body fatness were quantified and the percentage body fat determined according to published equations. RESULTS: Men and women had similar unadjusted M values. Within each gender and ethnic group M was inversely related to percentage body fat (r = -0.55 to -0.84; p < 0.05). After adjustment for percentage body fat, women were more insulin sensitive than men (10.1 vs 5.1 mg/kg/min among African-Americans and 10.1 vs 6.9 mg/kg/min among white, nonHispanics; p < 0.05 for each). When M was expressed per unit of fat free mass, women were still significantly more insulin sensitive than men (p < 0.05 for each ethnic group). In multivariate analyses, gender and percentage body fat were independently related to M in both ethnic groups accounting for 70% of the variance among African-American participants and 34% of the variance among white nonHispanic participants. CONCLUSION: The similar M values between men and women despite the higher percent body fat among women indicate that women are more insulin sensitive in muscle tissue than men. This was substantiated when M was normalized for fat free mass. This 'insulin advantage' may be related to the lower risk of coronary disease experienced by women and the loss of this advantage may in part underlie the stronger deleterious effects of diabetes that women suffer.

Original languageEnglish
Pages (from-to)76-82
Number of pages7
JournalInternational Journal of Obesity
Volume20
Issue number1
StatePublished - Jan 29 1996

Fingerprint

community health
insulin
Insulin
Health
body fat
Adipose Tissue
African Americans
nationalities and ethnic groups
Ethnic Groups
Fats
Body Weights and Measures
Glucose
glucose
Glucose Clamp Technique
gender
lipids
diabetes mellitus
muscle tissues
insulin resistance
cross-sectional studies

Keywords

  • Body fat
  • Gender
  • Insulin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

The female 'insulin advantage' in a biracial cohort : Results from the Miami Community Health Study. / Donahue, R. P.; Prineas, R. J.; DeCarlo Donahue, R.; Bean, J. A.; Skyler, Jay S.

In: International Journal of Obesity, Vol. 20, No. 1, 29.01.1996, p. 76-82.

Research output: Contribution to journalArticle

Donahue, R. P. ; Prineas, R. J. ; DeCarlo Donahue, R. ; Bean, J. A. ; Skyler, Jay S. / The female 'insulin advantage' in a biracial cohort : Results from the Miami Community Health Study. In: International Journal of Obesity. 1996 ; Vol. 20, No. 1. pp. 76-82.
@article{075cd046a1f14a8386ae130c3bf8da05,
title = "The female 'insulin advantage' in a biracial cohort: Results from the Miami Community Health Study",
abstract = "OBJECTIVE: To determine the extent to which gender differences in the rate of insulin-mediated glucose disposal are influenced by differences in body fatness. DESIGN: A cross-sectional study of a biracial sample of men and women drawn from a population-based study. SUBJECTS: Twenty-five 25-44 year old residents of Dade County, FL. Twenty-five African-Americans (14 men and 11 women) and 28 white, nonHispanics (15 men and 13 women). All participants were free of diabetes mellitus (WHO Criteria). MEASUREMENTS: All persons volunteered to undergo a hyperinsulinemic euglycemic clamp procedure to determine the rate of insulin-mediated glucose disposal (insulin sensitivity, M). Several measures of body fatness were quantified and the percentage body fat determined according to published equations. RESULTS: Men and women had similar unadjusted M values. Within each gender and ethnic group M was inversely related to percentage body fat (r = -0.55 to -0.84; p < 0.05). After adjustment for percentage body fat, women were more insulin sensitive than men (10.1 vs 5.1 mg/kg/min among African-Americans and 10.1 vs 6.9 mg/kg/min among white, nonHispanics; p < 0.05 for each). When M was expressed per unit of fat free mass, women were still significantly more insulin sensitive than men (p < 0.05 for each ethnic group). In multivariate analyses, gender and percentage body fat were independently related to M in both ethnic groups accounting for 70{\%} of the variance among African-American participants and 34{\%} of the variance among white nonHispanic participants. CONCLUSION: The similar M values between men and women despite the higher percent body fat among women indicate that women are more insulin sensitive in muscle tissue than men. This was substantiated when M was normalized for fat free mass. This 'insulin advantage' may be related to the lower risk of coronary disease experienced by women and the loss of this advantage may in part underlie the stronger deleterious effects of diabetes that women suffer.",
keywords = "Body fat, Gender, Insulin",
author = "Donahue, {R. P.} and Prineas, {R. J.} and {DeCarlo Donahue}, R. and Bean, {J. A.} and Skyler, {Jay S}",
year = "1996",
month = "1",
day = "29",
language = "English",
volume = "20",
pages = "76--82",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - The female 'insulin advantage' in a biracial cohort

T2 - Results from the Miami Community Health Study

AU - Donahue, R. P.

AU - Prineas, R. J.

AU - DeCarlo Donahue, R.

AU - Bean, J. A.

AU - Skyler, Jay S

PY - 1996/1/29

Y1 - 1996/1/29

N2 - OBJECTIVE: To determine the extent to which gender differences in the rate of insulin-mediated glucose disposal are influenced by differences in body fatness. DESIGN: A cross-sectional study of a biracial sample of men and women drawn from a population-based study. SUBJECTS: Twenty-five 25-44 year old residents of Dade County, FL. Twenty-five African-Americans (14 men and 11 women) and 28 white, nonHispanics (15 men and 13 women). All participants were free of diabetes mellitus (WHO Criteria). MEASUREMENTS: All persons volunteered to undergo a hyperinsulinemic euglycemic clamp procedure to determine the rate of insulin-mediated glucose disposal (insulin sensitivity, M). Several measures of body fatness were quantified and the percentage body fat determined according to published equations. RESULTS: Men and women had similar unadjusted M values. Within each gender and ethnic group M was inversely related to percentage body fat (r = -0.55 to -0.84; p < 0.05). After adjustment for percentage body fat, women were more insulin sensitive than men (10.1 vs 5.1 mg/kg/min among African-Americans and 10.1 vs 6.9 mg/kg/min among white, nonHispanics; p < 0.05 for each). When M was expressed per unit of fat free mass, women were still significantly more insulin sensitive than men (p < 0.05 for each ethnic group). In multivariate analyses, gender and percentage body fat were independently related to M in both ethnic groups accounting for 70% of the variance among African-American participants and 34% of the variance among white nonHispanic participants. CONCLUSION: The similar M values between men and women despite the higher percent body fat among women indicate that women are more insulin sensitive in muscle tissue than men. This was substantiated when M was normalized for fat free mass. This 'insulin advantage' may be related to the lower risk of coronary disease experienced by women and the loss of this advantage may in part underlie the stronger deleterious effects of diabetes that women suffer.

AB - OBJECTIVE: To determine the extent to which gender differences in the rate of insulin-mediated glucose disposal are influenced by differences in body fatness. DESIGN: A cross-sectional study of a biracial sample of men and women drawn from a population-based study. SUBJECTS: Twenty-five 25-44 year old residents of Dade County, FL. Twenty-five African-Americans (14 men and 11 women) and 28 white, nonHispanics (15 men and 13 women). All participants were free of diabetes mellitus (WHO Criteria). MEASUREMENTS: All persons volunteered to undergo a hyperinsulinemic euglycemic clamp procedure to determine the rate of insulin-mediated glucose disposal (insulin sensitivity, M). Several measures of body fatness were quantified and the percentage body fat determined according to published equations. RESULTS: Men and women had similar unadjusted M values. Within each gender and ethnic group M was inversely related to percentage body fat (r = -0.55 to -0.84; p < 0.05). After adjustment for percentage body fat, women were more insulin sensitive than men (10.1 vs 5.1 mg/kg/min among African-Americans and 10.1 vs 6.9 mg/kg/min among white, nonHispanics; p < 0.05 for each). When M was expressed per unit of fat free mass, women were still significantly more insulin sensitive than men (p < 0.05 for each ethnic group). In multivariate analyses, gender and percentage body fat were independently related to M in both ethnic groups accounting for 70% of the variance among African-American participants and 34% of the variance among white nonHispanic participants. CONCLUSION: The similar M values between men and women despite the higher percent body fat among women indicate that women are more insulin sensitive in muscle tissue than men. This was substantiated when M was normalized for fat free mass. This 'insulin advantage' may be related to the lower risk of coronary disease experienced by women and the loss of this advantage may in part underlie the stronger deleterious effects of diabetes that women suffer.

KW - Body fat

KW - Gender

KW - Insulin

UR - http://www.scopus.com/inward/record.url?scp=0030023381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030023381&partnerID=8YFLogxK

M3 - Article

VL - 20

SP - 76

EP - 82

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 1

ER -