TY - JOUR
T1 - The Face of Negative Affect
T2 - Trial-by-Trial Corrugator Responses to Negative Pictures Are Positively Associated with Amygdala and Negatively Associated with Ventromedial Prefrontal Cortex Activity
AU - Heller, Aaron S.
AU - Lapate, Regina C.
AU - Mayer, Kaitlyn E.
AU - Davidson, Richard J.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/8
Y1 - 2014/8
N2 - The ability to simultaneously acquire objective physiological measures of emotion concurrent with fMRI holds the promise to enhance our understanding of the biological bases of affect and thus improve our knowledge of the neural circuitry underlying psychiatric disorders. However, the vast majority of neuroimaging studies to date examining emotion have not anchored the examination of emotion-responding circuitry to objective measures of emotional processing. To that end, we acquired EMG activity of a valence-sensitive facial muscle involved in the frowning response (corrugator muscle) concurrent with fMRI while twenty-six human participants viewed negative and neutral images. Trial-by-trial increases in corrugator EMG activity to negative pictures were associated with greater amygdala activity and a concurrent decrease in ventromedial PFC activity. Thus, this study highlights the reciprocal relation between amygdalar and ventromedial PFC in the encoding of emotional valence as reflected by facial expression.
AB - The ability to simultaneously acquire objective physiological measures of emotion concurrent with fMRI holds the promise to enhance our understanding of the biological bases of affect and thus improve our knowledge of the neural circuitry underlying psychiatric disorders. However, the vast majority of neuroimaging studies to date examining emotion have not anchored the examination of emotion-responding circuitry to objective measures of emotional processing. To that end, we acquired EMG activity of a valence-sensitive facial muscle involved in the frowning response (corrugator muscle) concurrent with fMRI while twenty-six human participants viewed negative and neutral images. Trial-by-trial increases in corrugator EMG activity to negative pictures were associated with greater amygdala activity and a concurrent decrease in ventromedial PFC activity. Thus, this study highlights the reciprocal relation between amygdalar and ventromedial PFC in the encoding of emotional valence as reflected by facial expression.
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U2 - 10.1162/jocn_a_00622
DO - 10.1162/jocn_a_00622
M3 - Article
C2 - 24669790
AN - SCOPUS:84905159054
VL - 26
SP - 2102
EP - 2110
JO - Journal of Cognitive Neuroscience
JF - Journal of Cognitive Neuroscience
SN - 0898-929X
IS - 9
ER -