The eye: A window to the soul of the immune system

Victor L Perez Quinones, A. M. Saeed, Y. Tan, M. Urbieta, F. Cruz-Guilloty

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The eye is considered as an immune privileged site, and with good reason. It has evolved a variety of molecular and cellular mechanisms that limit immune responses to preserve vision. For example, the cornea is mainly protected from autoimmunity by the lack of blood and lymphatic vessels, whereas the retina-blood barrier is maintained in an immunosuppressive state by the retinal pigment epithelium. However, there are several scenarios in which immune privilege is altered and the eye becomes susceptible to immune attack. In this review, we highlight the role of the immune system in two clinical conditions that affect the anterior and posterior segments of the eye: corneal transplantation and age-related macular degeneration. Interestingly, crosstalk between the innate and adaptive immune systems is critical in both acute and chronic inflammatory responses in the eye, with T cells playing a central role in combination with neutrophils and macrophages. In addition, we emphasize the advantage of using the eye as a model for invivo longitudinal imaging of the immune system in action. Through this technique, it has been possible to identify functionally distinct intra-graft motility patterns of responding T cells, as well as the importance of chemokine signaling in situ for T cell activation. The detailed study of ocular autoimmunity could provide novel therapeutic strategies for blinding diseases while also providing more general information on acute versus chronic inflammation.

Original languageEnglish
Pages (from-to)7-14
Number of pages8
JournalJournal of Autoimmunity
Volume45
DOIs
StatePublished - Sep 1 2013

Fingerprint

Immune System
Autoimmunity
T-Lymphocytes
Posterior Eye Segment
Anterior Eye Segment
Lymphatic Vessels
Corneal Transplantation
Retinal Pigment Epithelium
Macular Degeneration
Immunosuppressive Agents
Chemokines
Cornea
Blood Vessels
Retina
Neutrophils
Macrophages
Inflammation
Transplants
Therapeutics

Keywords

  • Allo-transplantation
  • Cornea
  • Inflammation
  • Oxidative stress
  • Retina

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Perez Quinones, V. L., Saeed, A. M., Tan, Y., Urbieta, M., & Cruz-Guilloty, F. (2013). The eye: A window to the soul of the immune system. Journal of Autoimmunity, 45, 7-14. https://doi.org/10.1016/j.jaut.2013.06.011

The eye : A window to the soul of the immune system. / Perez Quinones, Victor L; Saeed, A. M.; Tan, Y.; Urbieta, M.; Cruz-Guilloty, F.

In: Journal of Autoimmunity, Vol. 45, 01.09.2013, p. 7-14.

Research output: Contribution to journalArticle

Perez Quinones, VL, Saeed, AM, Tan, Y, Urbieta, M & Cruz-Guilloty, F 2013, 'The eye: A window to the soul of the immune system', Journal of Autoimmunity, vol. 45, pp. 7-14. https://doi.org/10.1016/j.jaut.2013.06.011
Perez Quinones VL, Saeed AM, Tan Y, Urbieta M, Cruz-Guilloty F. The eye: A window to the soul of the immune system. Journal of Autoimmunity. 2013 Sep 1;45:7-14. https://doi.org/10.1016/j.jaut.2013.06.011
Perez Quinones, Victor L ; Saeed, A. M. ; Tan, Y. ; Urbieta, M. ; Cruz-Guilloty, F. / The eye : A window to the soul of the immune system. In: Journal of Autoimmunity. 2013 ; Vol. 45. pp. 7-14.
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