The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Treatments for autoimmune diseases including type 1 diabetes (T1D) are aimed at resetting the immune system, especially its adaptive arm. The innate immune system is often ignored in the design of novel immune-based therapies. There is increasing evidence for multiple natural killer (NK) subpopulations, but their role is poorly understood in autoimmunity and likely is contributing to the controversial role reported for NKs. In this review, we will summarize NK subsets and their roles in tolerance, autoimmune diabetes, and immunotherapy.

Original languageEnglish (US)
Article number109
JournalCurrent Diabetes Reports
Volume16
Issue number11
DOIs
StatePublished - Nov 1 2016

Fingerprint

Type 1 Diabetes Mellitus
Natural Killer Cells
Immunotherapy
Immune System
Autoimmunity
Autoimmune Diseases
Therapeutics

Keywords

  • Diabetes
  • Natural killer cells
  • Tolerance

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy. / Fraker, Christopher; Bayer, Allison L.

In: Current Diabetes Reports, Vol. 16, No. 11, 109, 01.11.2016.

Research output: Contribution to journalReview article

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