Abstract
Treatments for autoimmune diseases including type 1 diabetes (T1D) are aimed at resetting the immune system, especially its adaptive arm. The innate immune system is often ignored in the design of novel immune-based therapies. There is increasing evidence for multiple natural killer (NK) subpopulations, but their role is poorly understood in autoimmunity and likely is contributing to the controversial role reported for NKs. In this review, we will summarize NK subsets and their roles in tolerance, autoimmune diabetes, and immunotherapy.
Original language | English (US) |
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Article number | 109 |
Journal | Current Diabetes Reports |
Volume | 16 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1 2016 |
Keywords
- Diabetes
- Natural killer cells
- Tolerance
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism