The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy

Christopher Fraker; Allison L Bayer

doi:10.1007/s11892-016-0806-7

The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy

Christopher Fraker, Allison L Bayer

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Treatments for autoimmune diseases including type 1 diabetes (T1D) are aimed at resetting the immune system, especially its adaptive arm. The innate immune system is often ignored in the design of novel immune-based therapies. There is increasing evidence for multiple natural killer (NK) subpopulations, but their role is poorly understood in autoimmunity and likely is contributing to the controversial role reported for NKs. In this review, we will summarize NK subsets and their roles in tolerance, autoimmune diabetes, and immunotherapy.

Original language	English (US)
Article number	109
Journal	Current Diabetes Reports
Volume	16
Issue number	11
DOIs	https://doi.org/10.1007/s11892-016-0806-7
State	Published - Nov 1 2016

Keywords

Diabetes
Natural killer cells
Tolerance

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

Access to Document

10.1007/s11892-016-0806-7

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