Abstract
Treatments for autoimmune diseases including type 1 diabetes (T1D) are aimed at resetting the immune system, especially its adaptive arm. The innate immune system is often ignored in the design of novel immune-based therapies. There is increasing evidence for multiple natural killer (NK) subpopulations, but their role is poorly understood in autoimmunity and likely is contributing to the controversial role reported for NKs. In this review, we will summarize NK subsets and their roles in tolerance, autoimmune diabetes, and immunotherapy.
| Original language | English (US) |
|---|---|
| Article number | 109 |
| Journal | Current Diabetes Reports |
| Volume | 16 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1 2016 |
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Keywords
- Diabetes
- Natural killer cells
- Tolerance
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
Cite this
The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy. / Fraker, Christopher; Bayer, Allison L.
In: Current Diabetes Reports, Vol. 16, No. 11, 109, 01.11.2016.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy
AU - Fraker, Christopher
AU - Bayer, Allison L
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Treatments for autoimmune diseases including type 1 diabetes (T1D) are aimed at resetting the immune system, especially its adaptive arm. The innate immune system is often ignored in the design of novel immune-based therapies. There is increasing evidence for multiple natural killer (NK) subpopulations, but their role is poorly understood in autoimmunity and likely is contributing to the controversial role reported for NKs. In this review, we will summarize NK subsets and their roles in tolerance, autoimmune diabetes, and immunotherapy.
AB - Treatments for autoimmune diseases including type 1 diabetes (T1D) are aimed at resetting the immune system, especially its adaptive arm. The innate immune system is often ignored in the design of novel immune-based therapies. There is increasing evidence for multiple natural killer (NK) subpopulations, but their role is poorly understood in autoimmunity and likely is contributing to the controversial role reported for NKs. In this review, we will summarize NK subsets and their roles in tolerance, autoimmune diabetes, and immunotherapy.
KW - Diabetes
KW - Natural killer cells
KW - Tolerance
UR - http://www.scopus.com/inward/record.url?scp=84988662467&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84988662467&partnerID=8YFLogxK
U2 - 10.1007/s11892-016-0806-7
DO - 10.1007/s11892-016-0806-7
M3 - Review article
C2 - 27664042
AN - SCOPUS:84988662467
VL - 16
JO - Current Diabetes Reports
JF - Current Diabetes Reports
SN - 1534-4827
IS - 11
M1 - 109
ER -