@article{dea5166bdb4144999c1cd16240ddae3e,
title = "The expanding genetic overlap between multiple sclerosis and type I diabetes",
abstract = "Familial clustering of autoimmune disease is well recognized and raises the possibility that some susceptibility genes may predispose to autoimmunity in general. In light of this observation, it might be expected that some of the variants of established relevance in one autoimmune disease may also be relevant in other related conditions. On the basis of this hypothesis, we tested seven single nucleotide polymorphisms (SNPs) that are known to be associated with type I diabetes in a large multiple sclerosis data set consisting of 2369 trio families, 5737 cases and 10296 unrelated controls. Two of these seven SNPs showed evidence of association with multiple sclerosis; that is rs12708716 from the CLEC16A gene (P = 1.6 × 10-16) and rs763361 from the CD226 gene (P = 5.4 × 10-8). These findings thereby identify two additional multiple sclerosis susceptibility genes and lend support to the notion of autoimmune susceptibility genes.",
author = "Booth, {David R.} and Heard, {Robert N.} and Stewart, {Graeme J.} and An Goris and Rita Dobosi and B{\'e}n{\'e}dicte Dubois and Lorentzen, {{\AA}slaug R.} and Celius, {Elisabeth G.} and Harbo, {Hanne F.} and Anne Spurkland and Tomas Olsson and Ingrid Kockum and Jenny Link and Jan Hillert and Maria Ban and Amie Baker and Stephen Sawcer and Alastair Compston and Tania Mihalova and Richard Strange and Clive Hawkins and Gillian Ingram and Robertson, {Neil P.} and {De Jager}, {Philip L.} and Hafler, {David A.} and Barcellos, {Lisa F.} and Ivinson, {Adrian J.} and Margaret Pericak-Vance and Oksenberg, {Jorge R.} and Hauser, {Stephen L.} and McCauley, {Jacob L.} and David Sexton and Jonathan Haines",
note = "Funding Information: This work was supported by the National Multiple Sclerosis Society (AP 3758-A-16, RG 2899 and FG-1718-A1), grants from the NINDS (NS049477, NS032830 and NS26799), AI067152, the NIAID (P01 AI039671), an NMSS Collaborative Research Award (CA 1001-A-14) and the Penates Foundation. We acknowledge use of DNA from the British 1958 Birth Cohort collection, funded by the Medical Research Council Grant G0000934 and the Wellcome Trust Grant 068545/Z/02. The 1958 Birth Cohort samples were typed by John Todd and his group, and the resulting data made available by Neil Walker, we thank all the members of this team for generously providing these data. The Norwegian Bone Marrow Donor Registry is acknowledged for collaboration in establishment of the Norwegian control material. The Swedish sample was collected and analysed with the help of grants from the European Union fp6 program— NeuroproMiSe (LSHM-CT-2005-018637) and the Bibbi and Nils Jensens foundation. The Australian National Health and Medical Research Council is acknowledged for funding the collection and analysis of the Australian samples. AG is a Postdoctora Fellow and BD a Clinical Investigator of the Research Foundation Flanders (FWO-Vlaanderen). ARL is supported by The Research Council of Norway (166005/V5) and Odd Fellow MS society. We also thank the many healthy controls, multiple sclerosis patients and their families who participated in this study.",
year = "2009",
doi = "10.1038/gene.2008.83",
language = "English (US)",
volume = "10",
pages = "11--14",
journal = "Genes and Immunity",
issn = "1466-4879",
publisher = "Nature Publishing Group",
number = "1",
}