The executive prominent/memory prominent spectrum in Alzheimer's disease are highly heritable

Executive Prominent Alzheimer's Disease: Genetics and Risk Factors (EPAD:GRF), Alzheimer's Disease Neuroimaging Initiative (ADNI1), Alzheimer's Disease Genetics Consortium (ADGC)

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Late-onset Alzheimer's disease (LOAD) can present heterogeneously, with several subtypes recognized, including dysexecutive AD. One way to identify people with dysexecutive AD is to consider the difference between memory and executive functioning, which we refer to as the executive prominent/memory prominent spectrum. We aimed to determine if this spectrum was heritable. We used neuropsychological and genetic data from people with mild LOAD (Clinical Dementia Rating 0.5 or 1.0) from the National Alzheimer's Coordinating Center and the Alzheimer's Disease Neuroimaging Initiative. We cocalibrated the neuropsychological data to obtain executive functioning and memory scores and used their difference as a continuous phenotype to calculate its heritability overall and by chromosome. Narrow-sense heritability of the difference between memory and executive functioning scores was 0.68 (standard error 0.12). Single nucleotide polymorphisms on chromosomes 1, 2, 4, 11, 12, and 18 explained the largest fraction of phenotypic variance, with signals from each chromosome accounting for 5%-7%. The chromosomal pattern of heritability differed substantially from that of LOAD itself.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalNeurobiology of Aging
Volume41
DOIs
StatePublished - May 1 2016

Fingerprint

Alzheimer Disease
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 1
Neuroimaging
Single Nucleotide Polymorphism
Dementia
Chromosomes
Phenotype

Keywords

  • Atypical Alzheimer's disease
  • Dysexecutive Alzheimer's disease
  • Executive function
  • Genetics
  • Heritability
  • Memory

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Executive Prominent Alzheimer's Disease: Genetics and Risk Factors (EPAD:GRF), Alzheimer's Disease Neuroimaging Initiative (ADNI1), & Alzheimer's Disease Genetics Consortium (ADGC) (2016). The executive prominent/memory prominent spectrum in Alzheimer's disease are highly heritable. Neurobiology of Aging, 41, 115-121. https://doi.org/10.1016/j.neurobiolaging.2016.02.015

The executive prominent/memory prominent spectrum in Alzheimer's disease are highly heritable. / Executive Prominent Alzheimer's Disease: Genetics and Risk Factors (EPAD:GRF); Alzheimer's Disease Neuroimaging Initiative (ADNI1); Alzheimer's Disease Genetics Consortium (ADGC).

In: Neurobiology of Aging, Vol. 41, 01.05.2016, p. 115-121.

Research output: Contribution to journalArticle

Executive Prominent Alzheimer's Disease: Genetics and Risk Factors (EPAD:GRF), Alzheimer's Disease Neuroimaging Initiative (ADNI1) & Alzheimer's Disease Genetics Consortium (ADGC) 2016, 'The executive prominent/memory prominent spectrum in Alzheimer's disease are highly heritable', Neurobiology of Aging, vol. 41, pp. 115-121. https://doi.org/10.1016/j.neurobiolaging.2016.02.015
Executive Prominent Alzheimer's Disease: Genetics and Risk Factors (EPAD:GRF), Alzheimer's Disease Neuroimaging Initiative (ADNI1), Alzheimer's Disease Genetics Consortium (ADGC). The executive prominent/memory prominent spectrum in Alzheimer's disease are highly heritable. Neurobiology of Aging. 2016 May 1;41:115-121. https://doi.org/10.1016/j.neurobiolaging.2016.02.015
Executive Prominent Alzheimer's Disease: Genetics and Risk Factors (EPAD:GRF) ; Alzheimer's Disease Neuroimaging Initiative (ADNI1) ; Alzheimer's Disease Genetics Consortium (ADGC). / The executive prominent/memory prominent spectrum in Alzheimer's disease are highly heritable. In: Neurobiology of Aging. 2016 ; Vol. 41. pp. 115-121.
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