The evidence-based epidemiology of HCV-associated kidney disease

Fabrizio Fabrizi, Vivek Dixit, Paul Martin, Piergiorgio Messa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Novel information supports a definite link between hepatitis C virus (HCV) infection and chronic kidney disease (CKD) in the general population. HCV is associated with a large spectrum of histopathological lesions in both native and transplanted kidneys. Kidney disease is probably uncommon in HCV-infected patients even if its exact frequency remains unknown. The most common HCV-associated nephropathy is type I membranoproliferative glomerulonephritis, usually in the context of type II mixed cryoglobulinemia. Controversial information exists on the relationship between positive HCV serology and CKD but several surveys at population-based level suggest that infection with HCV per se is associated with an increased risk of having or developing renal insufficiency or proteinuria. According to a novel meta-analysis of observational studies (4 clinical studies, 93,919 unique individuals), positive HCV serology was an independent and significant risk factor for proteinuria; the summary estimate for adjusted relative risk is 1.55 with a 95% confidence interval (CI) of 1.14; 2.12, p = 0.0001 (random-effects model). The mechanisms of these associations appear complex, but both viral and non-viral processes have been implicated. Prospective studies are needed to fully characterize the exact impact of chronic HCV infection on kidney function trajectories over time.

Original languageEnglish
Pages (from-to)621-628
Number of pages8
JournalInternational Journal of Artificial Organs
Volume35
Issue number9
DOIs
StatePublished - Sep 1 2012

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Epidemiology
Kidney Diseases
Viruses
Hepacivirus
Virus Diseases
Serology
Chronic Renal Insufficiency
Proteinuria
Membranoproliferative Glomerulonephritis
Kidney
Cryoglobulinemia
Chronic Hepatitis C
Population
Observational Studies
Renal Insufficiency
Meta-Analysis
Trajectories
Prospective Studies
Confidence Intervals
Infection

Keywords

  • Chronic kidney disease
  • Hepatitis C virus (HCV)
  • Proteinuria
  • Renal insufficiency

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)

Cite this

The evidence-based epidemiology of HCV-associated kidney disease. / Fabrizi, Fabrizio; Dixit, Vivek; Martin, Paul; Messa, Piergiorgio.

In: International Journal of Artificial Organs, Vol. 35, No. 9, 01.09.2012, p. 621-628.

Research output: Contribution to journalArticle

Fabrizi, Fabrizio ; Dixit, Vivek ; Martin, Paul ; Messa, Piergiorgio. / The evidence-based epidemiology of HCV-associated kidney disease. In: International Journal of Artificial Organs. 2012 ; Vol. 35, No. 9. pp. 621-628.
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