The eucaryotic aminoacyl-tRNA synthetase complex: Suggestions for its structure and function

Murray P Deutscher

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Aminoacyl-tRNA synthetases from eucaryotic cells generally are isolated as high molecular weight complexes comprised of multiple synthetase activities, and often containing other components as well. A model is proposed for the synthetase complex in which hydrophobic extensions on the proteins serve to maintain them in their high molecular weight form, but are not needed for catalytic activity. The structural similarity of these enzymes to certain membrane-bound proteins, and its implications for synthetase localization and function in vivo, are discussed.

Original languageEnglish
Pages (from-to)373-377
Number of pages5
JournalJournal of Cell Biology
Volume99
Issue number2
StatePublished - Jan 1 1984
Externally publishedYes

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Amino Acyl-tRNA Synthetases
Ligases
Molecular Weight
Membrane Proteins
Enzymes
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

The eucaryotic aminoacyl-tRNA synthetase complex : Suggestions for its structure and function. / Deutscher, Murray P.

In: Journal of Cell Biology, Vol. 99, No. 2, 01.01.1984, p. 373-377.

Research output: Contribution to journalArticle

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