The epithelialisation phase in wound healing: Options to enhance wound closure

Majana Tomic-Canic, Lulu L. Wong, Hans Smola

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


This review highlights epithelialisation and therapeutic options to optimise and speed the epithelialisation process. To influence this process therapeutically, it is important for clinicians to understand the underlying principles of epithelialisation. The role of growth factors and the hostile local wound environment can explain why epithelial wound closure is so difficult to speed up in some chronic wounds. Clinicians should be aware of the different surgical techniques of skin grafting and more advanced technologies, such as skin substitutes, as options for wounds which fail to respond to standard protocols. Finally, novel dressing-based concepts are discussed, including macromolecular crowding, a concept which aims at boosting growth factor activities produced in the wound space once wound healing is normalised and underway..

Original languageEnglish (US)
Pages (from-to)646-658
Number of pages13
JournalJournal of Wound Care
Issue number10
StatePublished - Oct 2018


  • epithelialisation
  • growth factors
  • proteases
  • skin grafting
  • skin substitutes

ASJC Scopus subject areas

  • Fundamentals and skills
  • Nursing (miscellaneous)


Dive into the research topics of 'The epithelialisation phase in wound healing: Options to enhance wound closure'. Together they form a unique fingerprint.

Cite this