The Epigenetics of Medulloblastoma

Clara Penas, Vasileios Stathias, Bryce K. Allen, Nagi Ayad

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Medulloblastoma is the most common malignant pediatric brain tumor arising in the cerebellum or medulla/brain stem. Despite recent treatment advances, approximately 40% of children experience tumor recurrence and 30% will die from the disease. Several recent studies have shown that various epigenetic enzymes are either mutated or overexpressed in medulloblastoma. Thus, these enzymes are considered drug targets in medulloblastoma. Similarly, small RNAs named microRNAs are attractive for therapeutic intervention since they control expression of medulloblastoma tumor suppressors or oncogenes. Interestingly, strategies to modulate epigenetic enzymes and microRNAs simultaneously may be particularly attractive for medulloblastoma treatment. We highlight that the knowledge of epigenetic enzymes, microRNAs, in addition to kinase and ubiquitin ligase networks is especially important for designing combination therapies in medulloblastoma.

Original languageEnglish (US)
Title of host publicationEpigenetic Cancer Therapy
PublisherElsevier Inc.
Pages317-337
Number of pages21
ISBN (Print)9780128002247, 9780128002063
DOIs
StatePublished - Jul 22 2015

Keywords

  • Epigenetic enzyme
  • Histone acetyltransferase
  • Histone deacetylase
  • Medulloblastoma
  • Methyltransferases
  • MicroRNA
  • Sonic hedgehog

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Penas, C., Stathias, V., Allen, B. K., & Ayad, N. (2015). The Epigenetics of Medulloblastoma. In Epigenetic Cancer Therapy (pp. 317-337). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800206-3.00014-8