The epigenetic role of vitamin C in health and disease

Vladimir Camarena, Gaofeng Wang

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Recent advances have uncovered a previously unknown function of vitamin C in epigenetic regulation. Vitamin C exists predominantly as an ascorbate anion under physiological pH conditions. Ascorbate was discovered as a cofactor for methylcytosine dioxygenases that are responsible for DNA demethylation, and also as a likely cofactor for some JmjC domain-containing histone demethylases that catalyze histone demethylation. Variation in ascorbate bioavailability thus can influence the demethylation of both DNA and histone, further leading to different phenotypic presentations. Ascorbate deficiency can be presented systematically, spatially and temporally in different tissues at the different stages of development and aging. Here, we review how ascorbate deficiency could potentially be involved in embryonic and postnatal development, and plays a role in various diseases such as neurodegeneration and cancer through epigenetic dysregulation.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalCellular and Molecular Life Sciences
DOIs
StateAccepted/In press - Feb 4 2016

Fingerprint

Epigenomics
Jumonji Domain-Containing Histone Demethylases
Histones
Ascorbic Acid
Dioxygenases
DNA
Health
Biological Availability
Embryonic Development
Anions
Neoplasms

Keywords

  • DNA methylation
  • Epigenetics
  • Histone methylation
  • JmjC domain-containing histone demethylases
  • Methylcytosine dioxygenase
  • Scurvy
  • Vitamin C

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

The epigenetic role of vitamin C in health and disease. / Camarena, Vladimir; Wang, Gaofeng.

In: Cellular and Molecular Life Sciences, 04.02.2016, p. 1-14.

Research output: Contribution to journalArticle

@article{a8377d5c5e5642118488d8e8f347a6db,
title = "The epigenetic role of vitamin C in health and disease",
abstract = "Recent advances have uncovered a previously unknown function of vitamin C in epigenetic regulation. Vitamin C exists predominantly as an ascorbate anion under physiological pH conditions. Ascorbate was discovered as a cofactor for methylcytosine dioxygenases that are responsible for DNA demethylation, and also as a likely cofactor for some JmjC domain-containing histone demethylases that catalyze histone demethylation. Variation in ascorbate bioavailability thus can influence the demethylation of both DNA and histone, further leading to different phenotypic presentations. Ascorbate deficiency can be presented systematically, spatially and temporally in different tissues at the different stages of development and aging. Here, we review how ascorbate deficiency could potentially be involved in embryonic and postnatal development, and plays a role in various diseases such as neurodegeneration and cancer through epigenetic dysregulation.",
keywords = "DNA methylation, Epigenetics, Histone methylation, JmjC domain-containing histone demethylases, Methylcytosine dioxygenase, Scurvy, Vitamin C",
author = "Vladimir Camarena and Gaofeng Wang",
year = "2016",
month = "2",
day = "4",
doi = "10.1007/s00018-016-2145-x",
language = "English (US)",
pages = "1--14",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",

}

TY - JOUR

T1 - The epigenetic role of vitamin C in health and disease

AU - Camarena, Vladimir

AU - Wang, Gaofeng

PY - 2016/2/4

Y1 - 2016/2/4

N2 - Recent advances have uncovered a previously unknown function of vitamin C in epigenetic regulation. Vitamin C exists predominantly as an ascorbate anion under physiological pH conditions. Ascorbate was discovered as a cofactor for methylcytosine dioxygenases that are responsible for DNA demethylation, and also as a likely cofactor for some JmjC domain-containing histone demethylases that catalyze histone demethylation. Variation in ascorbate bioavailability thus can influence the demethylation of both DNA and histone, further leading to different phenotypic presentations. Ascorbate deficiency can be presented systematically, spatially and temporally in different tissues at the different stages of development and aging. Here, we review how ascorbate deficiency could potentially be involved in embryonic and postnatal development, and plays a role in various diseases such as neurodegeneration and cancer through epigenetic dysregulation.

AB - Recent advances have uncovered a previously unknown function of vitamin C in epigenetic regulation. Vitamin C exists predominantly as an ascorbate anion under physiological pH conditions. Ascorbate was discovered as a cofactor for methylcytosine dioxygenases that are responsible for DNA demethylation, and also as a likely cofactor for some JmjC domain-containing histone demethylases that catalyze histone demethylation. Variation in ascorbate bioavailability thus can influence the demethylation of both DNA and histone, further leading to different phenotypic presentations. Ascorbate deficiency can be presented systematically, spatially and temporally in different tissues at the different stages of development and aging. Here, we review how ascorbate deficiency could potentially be involved in embryonic and postnatal development, and plays a role in various diseases such as neurodegeneration and cancer through epigenetic dysregulation.

KW - DNA methylation

KW - Epigenetics

KW - Histone methylation

KW - JmjC domain-containing histone demethylases

KW - Methylcytosine dioxygenase

KW - Scurvy

KW - Vitamin C

UR - http://www.scopus.com/inward/record.url?scp=84957559320&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957559320&partnerID=8YFLogxK

U2 - 10.1007/s00018-016-2145-x

DO - 10.1007/s00018-016-2145-x

M3 - Article

SP - 1

EP - 14

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

ER -